Award Data

DESCRIPTION provided by applicant Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticated mass spectrometry Hydrophilic interaction liquid chromatography HILIC has great use in separations of glycopeptides and released glycans exhibitin ...

In the proposed effort, we will leverage this extensive experience and capabilities to realize a frequency agile mmW radiometer that can cover the range of DC-110 GHz and can be scaled to DC-200 GHz under Phase II. Ours is a photonic system that multiplies and up-coverts a low-frequency reference signal onto an optical carrier (laser) using EO modulation, then uses the modulation sidebands to inj ...

Current bolometers are broadband detectors and tend to absorb broad IR spectrum for thermal imaging. A key issue with these systems is the lack of sensitivity of the sensors in target detection due to blackbody radiation limit. As a result, one of the many important applications such as low concentration chemical detection cannot be performed. A solution to this problem is to employ cryogenic syst ...

Training in the symptoms of Spatial Disorientation (SD) has shown to be valuable in aiding pilots to recognize its onset and provide a means for mitigating its effects, but such demonstrations have traditionally been associated with specialized equipment and devices. Since the vast majority of pilots for the commercial aviation jet fleet are trained (or recertified) on 6-degree-of-freedom (DOF) h ...

THIS PHASE 1 PROJECT WILL RESULT IN DEVELOPMENT OF PIGMENTS, TATTOO EQUIPMENT AND PROCEDURES FOR VISUAL AND INSTRUMENTAL IDENTIFICATION OF DARK COLORED RODENTS. THE B6C3F1 BROWN MOUSE WILL BE USED AS A MODEL. VARIOUS BLACK AND COLORED PIGMENTS WILL BE EVALUATED ALONG WITH LIGHT SOURCES FOR VISUAL READING OF TAIL TATTOOS. IN ADDITION, OPTICAL CHARACTER RECOGNITION SCANNING OF TATTOOS WILL BE EMPLOY ...

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BECAUSE THERE IS NO KNOWN CURE FOR AIDS, NOR ANY CURES CURRENTLY ANTICIPATED, THE MOST EFFECTIVE RESPONSE TO THIS INTERNATIONAL EPIDEMIC MUST BE THROUGH EDUCATION AND PREVENTION. UNFORTUNATELY, OVER A THIRD OF U.S. YOUTHS IN LARGE CITIES HAVE ABANDONED SCHOOL AND, IN CONDUCTING THEIR LIVES IN THE CONTEXT OF STREET CULTURE, ARE AT HIGH RISK FOR CONTRACTING AIDS. PHASE I OF THIS PROJECT AIMS TO DEVE ...

THE IMMEDIATE GOAL IS TO DEVELOP AND OPTIMIZE AN AUTOMATED, SIMPLE HYBRIDIZATION TECHNIQUE USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) AND LIQUID HYBRIDIZATION TO REPLACE THE TIME-CONSUMING AND LABOR-INTENSIVE PROCEDURES OF GEL ELECTROPHORESIS, BLOTTING,AND SOLID-PHASE HYBRIDIZATION CURRENTLY NECESSARY FOR SUCH A ROUTINE AND BASIC FUNCTION AS HYBRIDIZATION. PRELIMINARY EXPERIMENTS DEMONSTR ...

THIS PROJECT WILL DEVELOP A SIMPLE, INEXPENSIVE PATCH THAT WILL TRANSDERMALLY DELIVER CONTRACEPTIVE DRUGS TO PATIENTS. THE PATCH WILL UTILIZE HERCON LABORATORIES CORPORATION'S PATENTED MULTILAYER POLYMERIC DISPENSER OF DRUGS, WHICH CONSISTS OF A RESERVOIR LAYER CONTAINING THE DRUG SEALED BETWEEN OUTER LAYERS. A PRESSURE-SENSITIVE ADHESIVE HOLDS THE PATCH ONTO THE SKIN; THE OUTERMOST LAYER IS IMPER ...

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