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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Assembled Porous Silica Membranes for Biomolecule SPE

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    Abstract Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher efficiency sample preparation processes Sample preparation before high resolution analytical methods such as HPLC or LC MS can require effort and cost nearly equivalent to the actual sample analysis and data reduction Often sample preparation for proteomic glycoproteom ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing an integrated sorting and single cell analysis tool for the analysis of rare T Cells subsets in Autoimmunity

    SBC: IsoPlexis            Topic: R

    Autoimmune disease AD affects up to million Americans which costs approximately $ billion on health care annually and accounts for one of the leading causes of death in women T cells and cytokine function play an important role in autoimmune diseases such as Type Diabetes Multiple Sclerosis Rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE The most successful auto i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Phase a clinical trial of ALK in geographic atrophy

    SBC: ALKEUS PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION provided by applicant The long term goal of this work is to develop an oral drug for the prevention of age related macular degeneration AMD AMD is the leading cause of blindness in the United States with million Americans diagnosed or at risk of irreversibly losing vision and over million people who already have debilitating vision loss Currently there is no FDA approved ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Glycosaminoglycans to Treat and Prevent Radiation Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    ABSTRACT Oral mucositis is a devastatingly painful inflammatory disease that frequently develops during cancer therapy and affects half a million people in the US The accompanying pain is so severe that patients often require narcotic pain medicines The clinical manifestations are ulcers in the mouth and gastrointestinal tract which are exacerbated by opportunistic infections Many patients al ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds II

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 300

    DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Single Cell Multi-Protein Device to Facilitate Cancer Immunotherapy

    SBC: IsoPlexis            Topic: 102

    DESCRIPTION provided by applicant The most promising immunotherapies against cancer rely upon modulating CD and various CD T cells to activate against cancers like melanoma lymphoma and leukemia However the ability for researchers to measure the secreted effector proteins per heterogeneous T cell which determine the cellular potency against the cancer is limited today This Phase ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Improved Protein Separations with Superficially Porous Particles

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 100

    DESCRIPTION provided by applicant Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic HPLC separations of larger molecules including proteins peptides glycopeptides and glycans Many HPLC separations of biomedical interest such as resolution of protein mixtures require an hour or more and ma ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. High throughput laboratory X-ray illumination system for protein crystallography and screening

    SBC: Sigray, Inc.            Topic: 100

    DESCRIPTION provided by applicant High throughput laboratory x ray illumination system for protein crystallography and screening X ray protein crystallography is the single most effective method to determine macromolecule structures such as proteins The understanding of the three dimensional structure of proteins gives key insight into their functionality and provides essential information ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A high resolution and high DQE detector optimized for mammography using single-shot bi-directional tri-contrast imaging

    SBC: Sigray, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant X ray tricontrast imaging provides three different modes of contrast absorption contrast the mechanism behind how conventional medical X ray imaging equipment images phase contrast which provides up to X more contrast than absorption based contrast for soft tissue and scatter contrast which provides information of features at dimensions smaller than ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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