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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of multimode vacuum ionization for use in medical diagnostics

    SBC: MSTM LLC            Topic: NIAID

    There is a critical need for rapid and cost-effective means for the detection of e.g. infectious diseases at an early stage, drug overdoses, and other health related testing necessities. Thus, significant commercial opportunities exist because of the lack of these capabilities as painfully “demonstrated” in the current pandemic. Mass spectrometry (MS), because of its ability to detect hundreds ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Amino Acids and Pediatric Hepatic Steatosis

    SBC: THE AMINO COMPANY LLC            Topic: 300

    7. Project Summary/Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in North America (1). Hepatic steatosis (HS) is the hallmark of NAFLD (2). NAFLD may transition in sub-groups to chronic inflammation (non- alcoholic steatohepatitis, NASH), and ultimately to cirrhosis. HS is prevalent in all stages of NAFLD. 3-10% of all children in the US and 40-70% of obese ch ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease

    SBC: EINSENCA INC.            Topic: NIA

    Alzheimer's disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. Aberrant neuroinflammatory response activates immune cells that can increase oxidative stress, and oxidative stress can directly damage neurons and axons, cause demyelination, and break down the blood-brain barrier (BBB). Thus, damagin ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. ARPA-H PHASE II SBIR AWARD, TOPIC 03- ROBOTICS FOR AUTONOMOUS SOFT TISSUE SURGERY TITLE: ADVANCED IMAGING AIDED AUTONOMOUS ROBOTIC CHOLECYSTECTOMY

    SBC: OPTOSURGICAL LLC            Topic: AH03

    This ARPA-H SBIR Phase II project aims to develop an 'autonomous' minimally invasive surgery approach, enhancing outcomes in procedures like laparoscopic cholecystectomy through advanced robotic tools and a 'smart' vision framework. The research team will explore whether the novel robotic platform can elevate the safety and efficiency of gallbladder removal surgery by integrating supervised autono ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. ARPA-H SBIR PHASE II TOPIC 4 FOR INTRA-OPERATIVE CONTRAST AGENTS

    SBC: OPTOSURGICAL LLC            Topic: AH04

    The project aims to advance the development of BL-760, a near-infrared contrast agent designed for clear intraoperative identification of bile ducts. This novel dye addresses the significant medical issue of bile duct injury during hepatobiliary surgeries (e.g., cholecystectomy, hepatectomy), impacting over 1 million patients annually. The project plans to produce BL-760 with high quality standard ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Live and Continuous Monitoring of Metal Cylinders and Tanks using Distributed Carbon Nanomaterial-based Sensing Networks

    SBC: MCET TECHNOLOGIES LLC            Topic: 22PH1

    This SBIR effort proposes using live and continuous monitoring of metal tanks, pressure vessels, and pipelines using carbon nanomaterial-based sensing skins to detect excessive physical strains, cracks, and to inspect impact damage. The proposed research and development work leverages 15+ years of fundamental research. The key objective is to advance the TRL level and the scalability of carbon nan ...

    SBIR Phase I 2022 Department of Transportation
  7. New Transformation Technology for Gene Editing of Human Mitochondrial DNA Associated With Mitochondrial Diseases

    SBC: NAPIGEN INC            Topic: 300

    PROJECT SUMMARY Human mitochondrial DNA (mtDNA) encodes 37 genes in a small genome of 16,569 bp, which accounts for 0.005% of the total human genome size. Despite the small size of this genetic information, mtDNA is indispensable to human cells. As mitochondria are critical for cellular respiration and ATP production, mitochondria are often referred to as “the Powerhouses of the cell”. Because ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. A Lateral Flow Assay for Rapid Saliva Fentanyl Detection (sFENTANYL)

    SBC: Instanosis, Inc.            Topic: NIDA

    Project Summary Fentanyl is a major contributor to the Opioid Epidemic. Rapid identification of the causative drug as fentanyl is critical for prompt and appropriate administration of naloxone, and the right level of clinical care. From the public health perspective, rapid identification of fentanyl is also key to overdose surveillance, outbreak recognition and communication among healthcare profe ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. hANDY-i(TM): A non-invasive, dual-sensor handheld imager for intraoperative preservation of parathyroid glands

    SBC: OPTOSURGICAL LLC            Topic: NIBIB

    Abstract Post-surgical hypoparathyroidism or hypocalcemia are known to occur frequently after thyroid surgeries due to the misidentification and/or accidental removal of healthy parathyroid glands. Approximately 150,000 thyroidectomies are performed in the US, 27% of these patients suffer from transient or permanent hypocalcemia, which can lead to lifelong sequelae and socioeconomic burden. Becaus ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Modulation of cancer induced immune suppression via inhibition of SCD1

    SBC: MODULATION THERAPEUTICS, INC.            Topic: NCI

    PROJECT SUMMARY Metabolic reprogramming plays a critical role in carcinogenesis, in part due its ability to promote immune suppressive properties within tumors. It remains unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicity. We show that inhibition of stearoyl CoA desaturase 1 (SCD1), the rate limiting enzyme involved in fatty-acid synthesis converting satura ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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