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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. NDT of Fracture Toughness for Pipeline Steels

    SBC: Fbs, Inc.            Topic: 180PH1

    NDT of Fracture Toughness for Pipeline Steels 3/16/2018 Ultrasound-based technology to nondestructively determine fracture toughness of pipeline steels will be developed. Fracture toughness is the material parameter that, along with applied loading and flaw geometry, dictates the critical crack size, and therefore controls the flaw size that must be detected during inspections. A major challeng ...

    SBIR Phase I 2018 Department of Transportation
  2. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two arm adaptive Phase II clinical trial to evaluate ONCa selective antagonist of the G protein coupled receptorGPCRdopamine receptor domainDRDin recurrent glioblastomaGBMand diffuse midline glioma associated with very poor prognoses and limited treatment optionsDRDis overexpressed in high grade gliomas and controls Akt ERK signaling pathwaysDownstream of target engage ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 363: myCare2- Supporting Caregivers and Caregiving

    SBC: BRIGHTOUTCOME INC.            Topic: NCI

    The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Development of PathDetect: Algorithms that Utilize Smartphone Sensor Data to Detect Adverse Pathway Conditions

    SBC: Pathway Accessibility Solutions, Inc.            Topic: na

    This project develops PathDetect, a smartphone app with algorithms that passively characterize adverse pathway conditions (APCs) as a wheelchair user traverses pedestrian pathways. As cities work to improve sidewalks and pedestrian walkways, accurate sidewalk assessments can provide important data to address APCs which can have a significant impact on older adults and individuals who use wheelchai ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Finding Human Carriers of Taeniasis to Prevent Neurocysticercois Associated Epilepsy

    SBC: APTAGEN LLC            Topic: ODCDC

    NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Topic 372: Development and Validation of Canine scFvs for Pre-Clinical Development of Targeted Therapeutics- Moonshot

    SBC: Vetigenics LLC            Topic: NCI

    The goal of this SBIR is to provide proof-of-concept of Vetigenics' canine-derived scFv phage display platform for rapid, cost effective production of highly versatile, canine-derived scFvs. scFvs against CD19, CD3 and CTLA4, three high-value, immunological molecules being targeted by antibody-based strategies in human cancer immunotherapy, will be isolated. Selected scFvs will be sequenced and bi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Topic 373: Monoclonal Antibodies to RNA-modifications

    SBC: Abzyme Therapeutics, LLC            Topic: NCI

    Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Nonsense Suppressing Drugs for Rett Syndrome

    SBC: Starwise Therapeutics LLC            Topic: 103

    Nonsense Suppressing Drugs for Rett Syndrome Rett syndromeRTTis a devastating genetic condition that affects mostly femalesIt is one of the worst types of neurodevelopmental disordersthe affected girls are born without any obvious problemsdevelop in a seemingly typical manner for the first year of lifebut then abruptly and without warning lose most of their acquired abilitiesRTT girls then typical ...

    SBIR Phase I 2018 Department of Health and Human Services

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