Award Data

Fracture toughness is the material parameter that, along with applied loading and flaw geometry, dictates the critical crack size, and therefore controls the flaw size that must be detected during inspections. A major challenge facing pipeline operators is that many pipelines are old, making their structural integrity uncertain, and that material pedigree of the pipeline steel is unknown. Therefor ...

This project develops and tests a Bluetooth compliant tongue-based electronic controller (a.k.a. “Mouth Mouse”), designed to give people with upper limb disability control of peripheral devices including computers and communication systems, home automation, and powered wheelchairs, as well as many other Bluetooth compliant devices and new technologies to come in the future. The Mouth Mouse is ...

TuberculosisTBkilled an estimatedmillion people in the world inOverof the mortalities associated with this deisease occurred in regions of the world where access to reliable TB testing and other suppotive infrastructure is severely limitedUntil there are pivotal technological innovations in the diagnosis of TB for point of carePOCapplicationthe ambitious goals of the WHO s End TB strategyareductio ...

Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

Taenia solium is a parasite acquired by pigs and transmitted to humans by eating or mishandling raw or undercooked infected porkIncidences primarily occur in areas with subsistence farming practices such as sub Saharan AfricaLatin Americaand AsiaIt affectsmillion people globallyCases of cystercercosis have been seen in the US and Canada due to globalizationIngested Taeniasolium oncospheres can mig ...

The goal of this SBIR is to provide proof of concept of Vetigenicscanine derived scFv phage display platform for rapidcost effective production of highly versatilecanine derived scFvsscFvs against CDCDand CTLAthree high valueimmunological molecules being targeted by antibody based strategies in human cancer immunotherapywill be isolatedSelected scFvs will be sequenced and binding affinities determ ...

Solid organ transplantation can be life savingHoweverimmunosuppression necessary to prevent rejection increases the incidence of cutaneous squamous cell carcinomacSCCfoldCurrent treatments for solid organ transplant recipientsSOTRsare largely surgicalwhich can be disfiguring and impact quality of lifeThere is a huge need for a safe and effective chemoprevention agent for cSCC in SOTRsThe RAF MEK E ...

The prohibitive cost of cancer care has been widely describedCancer treatment received by patients with insurance can still result in a considerable financial burdenNon adherence is one of the best studied outcomes resulting from higher care costsFinancial distress has also been linked to changes in treatment related decision makingincluding the decision against a treatment course because of costA ...

The Contractorwill use modern technology to develop a fully integratedcommercially viable device for controlled pharmaceutical drug detectiondeactivationand disposal to ensure compliance with DEA regulations and deter opioid theft

Abstract Our goal is to develop a product that will objectively measure pain using computer vision and machine learning technologies together with tablet based self reported pain data from patients for research or clinical purposesOur device will be low cost because it will consist of one or two cameras to record the video and a computer to analyze the video in almost real timeThe software of the ...