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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 3171 results
  1. An innovative telomerase-targeted, circulating tumor cell assay for monitoring NSCLC treated with radiation and immunotherapy

    SBC: Liquid Biotech USA, Inc.            Topic: 102

    Project Summary: Cancer is a leading cause of death both in the United States and across the world, claiming over 600,000 and 8 million deaths each year, respectively. Delayed detection of cancer progression or recurrence after treatment contributes to increased morbidity and rapid death, but re-biopsy or repeat surgery is usually not possible due to severe risks. The accuracy of conventional imag ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials Abstract The critical importance of solid-state NMR (ssNMR) was recently demonstrated by, after nearly two decades of intense efforts, yielding the first atomic-resolution structures of the A40 and A42 amyloid fibrils that play a crucial role in Alzheimer’s Disease (AD). Challenges posed by the ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a PCR assay for quantitative detection of HBV cccDNA

    SBC: JBS SCIENCE INC            Topic: NIAID

    Development of a PCR assay for quantitative detection of HBV cccDNA There is an urgent and unmet need for an effective method to detect hepatitis B virus (HBV) cccDNA in the blood. HBV infection affects nearly 350 million people worldwide. Chronic HBV infection is a major risk factor for the development of severe liver diseases such as cirrhosis and hepatocellular carcinoma, which has a poor survi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Trypanocidal Agents that Kill Multiple Stages of the Trypanosoma cruzi Life Cycle

    SBC: FOX CHASE CHEMICAL DIVERSITY CENTER INC.            Topic: NIAID

    Abstract. Chagas disease is a neglected tropical disease and has been designated as a research priority by NIAID and an SBIR Research Topic of Interest. Six million individuals are infected and 8,000 deaths were caused by Chagas in 2015 in mostly Central and South America by advanced forms of the disease such as Chagas hemorrhagic fever. The cost associated with Chagas disease treatment globally i ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Combined Biomarker and EMR Data for Heterogeneous Treatment Effects and Surrogate Endpoints in Sepsis

    SBC: PRENOSIS INC            Topic: 300

    Principal Investigator/Program Director (Last, first, middle): Reddy, Jr., Bobby Project Summary: Sepsis is a poorly understood clinical syndrome characterized by dysregulated host response to infection. The complexity and heterogeneity of the host response has frustrated attempts at developing effective treatments. In partnership with 6 U.S. hospitals, Prenosis amassed NOSIS, one of the world’s ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. A single antiviral to treat multiple opportunistic infections

    SBC: EVRYS BIO LLC            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT Immunosuppressed transplant patients have heightened susceptibility to environmental pathogens as well as adventitious agents traveling with donor tissues or resident in the recipient. Traditional therapies target the virus and are thereby limited in effectiveness to the specific virus targeted. Evrys Bio is developing orally administered, broad-spectrum antivirals that ta ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Development of A Novel Nanoparticle Biosensor for Rapid, Point-of-Care Sepsis Diagnosis and Risk Assessment

    SBC: NAMI DIAGNOSTICS LLC            Topic: NIAID

    Abstract. In the United States, about 1.7 million adults affected by sepsis annually, which leads to more than 270,000 deaths per year. If sepsis cannot be diagnosed and treated early, it not only causes high morbidity and mortality rates, but also poses a major burden to the healthcare system since septic patients are generally hospitalized for extended stay and rarely discharged from ICU before ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. High-throughput profiling of proteases with phage and arrays

    SBC: Tango Biosciences Inc.            Topic: NIAID

    Proteases represent an important class of enzymes in all eukaryotic cells where they play critical roles in activating and destroying proteins during cell growth, development, cell signaling, apoptosis, and autophagy. Misregulation, however, can lead to disease; for example, cancer cells often secrete metalloproteases that degrade the extracellular matrix, permitting cancers cells to metastasize a ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a tele-mentoring system integrated into an ultra-portable surgical microscope to treat cataract in underserved populations

    SBC: X-BIOMEDICAL INC            Topic: NEI

    Currently, in austere environments like the rural regions of Africa, there are millions of people who go blind each year due to cataract. This is an easily preventable condition if they receive the correct treatment in a timely manner. Unfortunately, there is a growing shortage of ophthalmologists and other surgeons throughout the world, and in many African countries unsupervised non-physicians pe ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Waveguide to Enable MAS-DNP-NMR in Standard-bore High-field Magnets

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Novel Waveguide to Enable MAS-DNP-NMR in Standard-bore High-field Magnets Abstract The critical importance of solid-state NMR (ssNMR) was recently demonstrated by, after nearly two decades of intense efforts, yielding the first atomic-resolution structures of the A?40 and A?42 amyloid fibrils that play a crucial role in Alzheimer’s Disease (AD). Key to that structure determination was a techni ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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