Award Data

DESCRIPTION (provided by applicant): Respiratory distress syndrome (RDS) is an acute, severe pulmonary disorder that is the leading cause of morbidity and mortality in preterm infants. It is a major healthcare concern - costs associated with treatment of RDS and its complications exceed 2.4 billion annually in the US. Currently, animal-derived surfactants instilled intratracheally via an endotrac ...

DESCRIPTION provided by applicant Exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions including the detonation of andquot dirty bombsandquot is a significant public health concern The lung is particularly susceptible to ionizing radiation injury from external sources or inhalation of radioactive particles from radioactive fall out Radiation pneumono ...

DESCRIPTION provided by applicant Cells require the ability to detect and respond to stimuli in their surroundings including to endogenous metabolites exogenous nutrients and environmental irritants The proteins that are responsible for this process are called chemosensors and are involved in regulating diverse biological processes involved in pain sensation dietary preference and metabol ...

DESCRIPTION provided by applicant Acute and chronic pain resulting from injury surgery or disease afflicts andgt million Americans each year having a severe impact on mood mental health and quality of life and costing the U S approximately $ billion in economic costs annually For many patients treatment options provide inadequate relief because of the shortcomings of available th ...

DESCRIPTION provided by applicant Systemic fungal infections are increasingly common especially in immune compromised patients While new antifungal drugs have been developed there is still a high mortality associated with these infections especially those due to Candida albicans other non albicans species NAS This is due to the limited spectrum of the drugs significant side effects as ...

DESCRIPTION provided by applicant AMPA glutamate receptors mediate the majority of fast excitatory neurotransmission in the central nervous system Four AMPA receptor subunits exist GluA GluA with functional channels containing various combinations of these four subunits Dysregulation of AMPA receptor expression has been reported in many neurological disorders including amyotrophic latera ...

DESCRIPTION provided by applicant The goal of this research program is to develop a novel small molecule inhibitor of latent Epstein Barr Virus EBV infection EBV is a ubiquitous gamma herpesvirus that has been classified by the World Health Organization as a human carcinogen Vironika with its consortium partners the Wistar Institute and Fox Chase Chemical Diversity Center Inc will deve ...

DESCRIPTION provided by applicant Cystic fibrosis CF leads to chronic illness disability and early death Recurrent pulmonary infections are lethal owing to growth of bacteria and other microorganisms in the abnormally viscous mucus Antibiotics mucolytics and anti inflammatory agents are useful only in treating some CF effects Recently however ivacaftor a k a VX or Kalydeco w ...

DESCRIPTION provided by applicant Heart disease is the leading cause of death for both men and women in the US accounting for nearly of all annual deaths A high cholesterol level is well known risk factors for heart disease Although blood cholesterol can be lowered using a number of marketed drugs of which statins are the leading drugs only of patients taking these drugs are achiev ...

DESCRIPTION provided by applicant The ubiquitin proteasome pathway degrades of cellular proteins and is of great interest as a source of new therapeutics for multiple diseases The pre proteasomal phase of the pathway catalyzed by the ubiquitin E activating enzyme E conjugating enzyme and E ligase is predicted to afford drugs that act more selectively than proteasome inhibitors ...