Award Data

DESCRIPTION (provided by applicant): The long-term goal of this program is to identify and develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism and angiogenesis, we have focused on SK as an innovative molecular target for the development of new drugs for the treatment of diabetic retinopathy. Sph ...

DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development of new drugs for the treatment of Inflammatory Bowel Diseases (IBDs). Sphingolipids are b ...

DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective for the treatment of arthritis. Sphingolipids are being increasingly recognized as key mediators of apoptosis, stress responses, cell differentiation and proliferation, and are known to regulate the inflammatory cascade of central importance in ...

DESCRIPTION (provided by applicant): To address wayfinding difficulties and physical activity among cognitively-impaired older adults, we propose to develop a navigation aid that can be attached to three- and four-wheeled rollators. The navigation aid will provide navigation assistance to the user and will track the user's movements for later analysis by caregivers. Navigation assistance will be p ...

DESCRIPTION (provided by applicant): Users of standard manual wheelchairs sometimes lack the endurance for extended travel or may be temporarily fatigued enough to need assistance with wheeled mobility. Elderly manual wheelchair users in nursing homes and assisted living facilities find their independence restricted by their lack of ability or their self-confidence to embark on extended travel wit ...

DESCRIPTION (provided by applicant): The long-term goal of this project is the development of radiopharmaceuticals for diagnosis of Alzheimer's disease (AD). The project is driven by the hypothesis that in vivo detection of amyloid plaques by positron emission computed tomography imaging (using radiolabeled amyloid binding probes) would allow for the early and definitive diagnosis of AD. A nove ...

DESCRIPTION (provided by applicant): The long-term goal of this project is the development of radiopharmaceuticals for diagnosis of Dementia with Lewy Bodies (DLB). DLB is the second most common cause of dementia in the United States; although the disease requires specific pharmacologic management, current diagnostic methods are extremely inaccurate. DLB is often misdiagnosed as Alzheimer's dise ...

DESCRIPTION (provided by applicant): There is growing recognition that surgical repair of the heart is most likely to be successful in infancy (when there is dramatic capacity for growth and remodeling). For a subset of patients, the optimal time for intervention is prior to birth. Current prenatal cardiac intervention (PCI) procedures clearly have technical limitations in both fetal visualizat ...

DESCRIPTION (provided by applicant): Remarkable progress has been made over the last decade on ventricular assist devices for adult heart failure patients. Thousands of patients' lives have been saved each year. Unfortunately, similar devices are not yet available in the US for pediatric heart patients. Development of such devices has been impeded by the fact that the pediatric market size is t ...

DESCRIPTION (provided by applicant): Contrast agent harmonic imaging has become a very important tool for studying blood perfusion. Due to the extensive amount of angiogenesis that occurs around malignant tumors, the use of ultrasound contrast agents has the potential to improve cancer diagnosis and to direct therapies. However, existing transducers are limited in their ability to form images from ...