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Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

ABSTRACTThe global death toll from Malaria is estimated to be upwards ofpeople each yearwith more thanchildren succumbing every dayPlasmodium falciparumPfSporozoiteSPZbased vaccines are the only intervention in humansproven to induce robusthigh levelandgtand long lastingat leastmonthsprotective efficacy against malariaforming the basis of Sanaria s unique technology platform of asepticpurifiedcryo ...

There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

NDT of Fracture Toughness for Pipeline Steels 3/16/2018 Ultrasound-based technology to nondestructively determine fracture toughness of pipeline steels will be developed. Fracture toughness is the material parameter that, along with applied loading and flaw geometry, dictates the critical crack size, and therefore controls the flaw size that must be detected during inspections. A major challeng ...

Reading Barcode Signs to Support V21 Safety 3/20/2018 For this SBIR we will develop a machine vision system which uses onboard standard-resolution cameras in vehicles to identify and read barcode signs on the roadside. The proposed approach could provide a low-cost solution that make connected and automated vehicle (CAV) technology viable for rural areas with limited access to Information and ...

An Artificial Intelligence (AI) Traffic Data Analysis Tool for Advanced Freeway Traffic Management 3/20/2018 Planned or unplanned traffic events cause various magnitude of traffic congestion and safety impact to road users. It was estimated that 60% of congestions are non-recurrent and 15% of incidents are secondary to the primal accidents. Thus local or regional Traffic Management Centers (T ...

Proposal title: Rapid Assessment of Air Void in System in Fresh Concrete Air void parameters such as specific surface (SS) and spacing factor (SF) are essential in evaluating Freeze-Thaw (F-T) durability in fresh concrete. We have demonstrated the feasibility and viability of using an acoustic method to measure in near real time air void distributions in fresh concrete, the proposed solution is b ...

This project develops new methods for fabricating replicas of museum artifacts and other 3D objects that describe themselves when touched, so that museums can create exhibits that are accessible to everyone, including visitors with visual impairments. Phase I demonstrated how ordinary capacitive touchscreens could be repurposed as sensors for determining locations of finger touches on 3D surfaces ...

NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

The development of a healthy behaviors through active design tool supports the initiatives focused on nutritionphysical activityand obesity by utilizing an evidence based web application to offer design solutions that influences healthy choicesThis feasibility study provides a prototype and establishes the commercial merit of the resulting research based applicationproviding health and wellness fe ...