Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. CAD-CAM Technology for Diabetic Footwear

    SBC: DIAPEDIA, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diabetes remains the leading cause of non-traumatic lower extremity amputations. Most amputations are preceded by a foot ulcer, so that successfully treating, or better still preventing, foot ulcers should reduce the n umber of diabetes related amputations. The majority of foot ulcers in diabetic patients are the result of loss of protective sensation (LOPS) s ...

    SBIR Phase II 2008 Department of Health and Human Services
  2. Biocompatible Coating for Pediatric Blood Oxygenators- Phase II

    SBC: ENSION Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Many oxygenators clinically available for pediatric (and adult) extracorporeal membrane oxygenation (ECMO) utilize heparin coatings such as Carmeda BioActive Surface on device surfaces, including the microporous hollow fibers, to improve biocompatibility. Despite application of these coatings, significant inflammatory and coagulation-related complications, as ...

    SBIR Phase II 2008 Department of Health and Human Services
  3. Sprayable Surgical Adhesive for Seroma Prevention

    SBC: COHERA MEDICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this project is to create a sprayable surgical adhesive which would satisfy the surgical need for a strong, easy-to-use adhesive to adhere planar flaps of tissue. This novel adhesive will reduce fl uid accumulation after surgery by eliminating dead space in the wound and maintaining tissues in position for natural healing to occur. Seroma ...

    SBIR Phase II 2008 Department of Health and Human Services
  4. Novel Nitrogen Enriched Air for Fire Suppression

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this Compact Membrane Systems (CMS) program is to develop a new platform technology for fire suppression and fire prevention systems around membrane supplied nitrogen enriched air (NEA). The limitation that the atmospheres used in the fire suppression be breathable to occupants in the proximity of a fire is easily accomplished by CMS technolog ...

    SBIR Phase II 2008 Department of Health and Human Services
  5. Cell-free Detection of GPCR Signaling in a Nanoscale System

    SBC: INTEGRAL MOLECULAR, INC            Topic: N/A

    DESCRIPTION (provided by applicant): G protein-coupled receptors (GPCRs) are one of the most important families of pharmaceutical targets. However, some of the most desirable types of GPCR drugs have also been some of the most difficult to discover. GPCRs are integral membrane proteins that are traditionally studied in live cells or cell membrane preparations, sources that limit the ability to pu ...

    SBIR Phase II 2008 Department of Health and Human Services
  6. SUMO Fusions to Enhance Expression of Membrane Proteins

    SBC: LIFESENSORS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Rather modest success has yet been achieved in expressing and purifying membrane proteins as a prerequisite to obtain high resolution structures. Only 124 unique structures for membrane proteins have been resolved out o f gt 30,000 soluble proteins. This bottleneck can be divided into at least three major parts: i) the difficulty to express quantitatively and ...

    SBIR Phase II 2008 Department of Health and Human Services
  7. Mental Health Outcomes in Abused Women

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Domestic violence is a pervasive problem in our society that impacts women and their families as well as the multiple social institutions and agencies that must grapple with its effects: Child Welfare, Mental Health, La w Enforcement, and Domestic Violence. Women who are abused are likely to find themselves in a pattern of revictimization, endangering not just ...

    SBIR Phase II 2008 Department of Health and Human Services
  8. Sphingosine Kinase Inhibitors as Anti-Arthritis Agents

    SBC: Apogee Biotechnology Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine 1-phosphate produced by sphingosine kinase (SK) mediates the effects of tumor necrosis factor-1 and interleukin-12, pro-inflammatory cytokines ...

    SBIR Phase II 2008 Department of Health and Human Services
  9. Novel Antagonists of the ORL-1 Receptor

    SBC: ADOLOR CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 2001 Department of Health and Human Services
  10. Development of a cost-effective pmMRI for in vivo structural examination of bone

    SBC: MICROMRI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): MicroMRI, Inc. Development of a cost-effective pfMRI for in vivo structural examination of bone Abstract Osteoporosis is a systemic bone disease characterized by low bone mass and abnormal bone quality. The current "gold standard", dual-energy x-ray absorptiometry (DXA), cannot assess bone quality and fails to detect > 50% of persons at greatest risk of fractur ...

    SBIR Phase II 2008 Department of Health and Human Services
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