Award Data

Summary In this fast track Phase I II STTR project a novel mass spectrometry method and a matched reagent kit will be developed for mapping modified nucleotides in human mitochondrial transfer RNA mt tRNA including the most abundant modification pseudouridine which hitherto has proved to be a technical challenge because it is an isomer of uridine These new research tools will be harnessed t ...

ABSTRACT Membrane proteins control the flow of informationnutrientsand signals through the cell membraneand are the targets forof FDA approved drugsMonoclonal antibodiesMAbsthat target membrane proteins can be exceptionally valuable in researchdiagnosticand therapeutic applicationsbut for the vast majority of membrane proteins there are either no MAbs at all or only poor quality antibodies with li ...

Project Summary DIApediaLLCfunded by the National Institutes of Health SBIR programhas developed an advanced diabetic foot orthosis systemDIApedia s TrueContourcustom diabetic foot orthosesCDFOare designed by combining the patient s unique foot shape with customized offloading modifications of the orthosis surface that are based on the patient s unique measured plantar pressureTrueContourCDFOs hav ...

Product Development for Bromodomain NetworksAbstractEpigenetic regulation of gene expression is a highly dynamic and reversible process essential to normal cellular functionHoweverit also contributes to human diseasessuch as cancer and inflammationProtein families that participate in epigenetic regulation include writerswhich covalently modify chromatinreaderswhich recognize chromatin modification ...

AbstractProject Summary Cognition Therapeutics IncCogRxhas discovered CTa novel oligomer receptor antagonist that is the only drug candidate demonstrated to prevent and displace binding of Abeta oligomers to receptors on brain cellsBy stopping the initiating event in the Abeta oligomer cascadethis first in class drug candidate completely blocks downstream synaptotoxicity and restores memory to nor ...

PROJECT SUMMARYABSTRACT The overall goal of the proposed SBIR project is to commercialize an Integrated Continuous and Single use bio production platformICSfor flexible and robust manufacturing of therapeutic proteinsThis novel platform will enable continuoussingle useand low cost purification of therapeutic proteinsSuccessful commercialization of the ICS system will lead to at least areduction in ...

Adoptive transfer of autologous T cells engineered to express chimeric antigen receptorsCARshas emerged as a promising immunotherapy for patients with hematologic malignanciessuch as CDCARs in leukemias and lymphomasHoweverchallenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell productsince infused cellsasliving drugscan be activated and release a varie ...

Summary One in seven people worldwide suffers from a brain disordere gepilepsyParkinson sstrokeor dementiaDevelopment of future treatments depends on improving our understanding of brain function and diseaseand validating new treatments critically depends on identifying the underlying biomarkers associated with different conditionsBiomarker discovery requires volumequalityrichnessand diversity of ...

ABSTRACT Hemorrhagic cystitisHCis an inflammatory illness marked by bleeding in the bladder and urinary painHC is a complication of radiation therapy and chemotherapy used to treat cancers of the pelvic area prostateovariancervicalbladderand colorectalBecause the bladder exhibits slow cell turnoverHC can emerge months or years after such procedures and once HC occursit often continues to re occurH ...

Searching for street parking, a behavior known as cruising for parking, leads to excess congestion and pollution. Many recent smart parking interventions have attempted to address this issue, but the problem of effectively detecting and measuring cruising remains largely unsolved. The goal of this work is to develop methods to detect and measure cruising for parking and its effects on congestion u ...