Award Data

Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

NDT of Fracture Toughness for Pipeline Steels 3/16/2018 Ultrasound-based technology to nondestructively determine fracture toughness of pipeline steels will be developed. Fracture toughness is the material parameter that, along with applied loading and flaw geometry, dictates the critical crack size, and therefore controls the flaw size that must be detected during inspections. A major challeng ...

TECHNICAL ABSTRACT: We propose developing a new observational capability for measuring upper atmosphere (20-Km to 200-Km+ altitude) wind and temperature dynamics, based on Doppler imaging of Limb concentrations of NO, N2O, and CO2 called the Doppler Wind Temperature Sounder. The principle of operation is that by measuring the Doppler shift of trace gases created by the differential velocity betwee ...

Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

This Fast track SBIR developstestsand commercializes aPiezoelectric Ring Mounted Oscillated Syringe System for Lower DistressLower ForceLaboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal WelfareThe Oscillated Needle InserterONIis a simple one handedvascular access device that uses a novel vibratory piezoelectric ring to directly apply longitudinal microos ...

Project Summary The ability to perform platelet separation with a high throughputhigh recovery ratehigh purityand high platelet integrity is extremely important in many biomedical research studies and therapeutic applicationssuch as platelet transfusionsCentrifugation is currently thegold standardlaboratory technique used to obtain platelets from whole bloodHoweverthis current approach for platele ...

Low dose CT screeningLDCThas been approved by the Centers for Medicare andampMedicaid ServicesCMSfor Medicare coverageHoweverthe primary problem associated with CT is the high false positivedetectionsThis issue often leads to unpleasant and costly unintended consequencese gfollow up scans and or invasive biopsiesIn this projectwe propose to develop and commercializea novel computer tool to aid in ...

Project Summary Drug development has become an extremely expensive and time consuming processIt is for this reason that many efforts are being made to overhaul how potential drugs are brought to marketBy lowering the cost in the developmental and testing phasesthe inflated end costs can be controlledThe use of model organisms as a cheaper explorative method prior to human testing hasand must conti ...