Award Data

DESCRIPTION (provided by applicant): Mammography is the benchmark for breast disease detection and diagnosis. However, it can miss 10-15% of early stage breast cancers, and it is unable to distinguish between benign and malignant lesions with certainty. Av ailability of an alternate method e.g. biomarker based, which allows early detection/precise distinction between benign disease and breast canc ...

This Small Business Innovative Research Phase I project will develop an innovative High Velocity Particle Consolidation system using liquid particle acceleration mechanisms for Cold Spray applications. Conventional Cold Spray uses high pressure process gas to accelerate particles to a critical velocity, so that upon impact with a substrate, the particles plastically deform and create a coating. ...

DESCRIPTION (provided by applicant): The product that will result from this SBIR program, proposed by Vironika and its consortium partner, The Wistar Institute, is a new (the first) small molecule drug candidate for Epstein-Barr virus (EBV) latent infection, and its associated pathologies. EBV is a prevalent human herpesvirus that has been classified by the World Health Organization as a human car ...

In this proposal, AlphaSense, Inc. (AI) and the Oklahoma State University (OKState) detail the development of a novel Cavity Enhanced Terahertz Absorption Spectrometer (CETAS). Key innovations of the proposed system include: a) the use of a small Whispering- Gallery- Mode (WGM) cavity to achieve very long pathlength; and b) the integration of the WGM cavity with the conventional pulsed and continu ...

In this proposal, AlphaSense, Inc. proposes to develop an innovative real time probe for online monitoring of plastic bonded explosive manufacturing process. Key innovations of the proposed sensor probe include: a) the use of a white light interferometer (WLI) to form real time images of the particles for accurate particle size measurements, and b) the use of quartz crystal microbalance (QCM) base ...

DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine 1-phosphate produced by sphingosine kinase (SK) mediates the effects of tumor necrosis factor-1 and interleukin-12, pro-inflammatory cytokines ...

DESCRIPTION (provided by applicant): Fast and effective communication is the key to minimizing confusion, anxiety, and casualties both during and after a public health emergency. The ability of emergency services personnel to relay clear instructions, part icularly to vulnerable populations, results in better understanding of the situation by the population and faster compliance with these instruc ...

Artisan Laboratories Corporation proposes to develop high density, high performance RF over fiber technology. Artisan’s approach to the technology is to design for high efficiency and high volume production that saves size, weight and power plus cooling by taking advantage of advanced modulation, transmission and packaging techniques. Artisan has developed highly efficient RF over fiber links an ...

This proposal addresses the need for a smart, network-compatible, enhanced head-aimed video sensor system to enable geo-location and target hand-off from robotic platforms. The sensor system provides enhanced remote situational awareness, with specific features aimed towards reconnaissance and surveillance, and target identification and designation missions. This same sensor is also applicable t ...

DESCRIPTION (provided by applicant): The product that will result from this proposal will be a potent biological regulator of innate immunity, 1- peptidyl-2,3-diacylglyceride (PDAG), for use in the prevention of hospital-acquired (nosocomial) infections in highly-susceptible patient populations. Nosocomial infection is a rapidly growing cause of morbidity and mortality in U.S. hospitals and nosoc ...