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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. High throughput screening of bacterial collections for surface proteins of commer

    SBC: APD LIFE SCIENCES, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): There is a recognized need for development of protein capture tools that will reliably detect a variety of targets, over a broad range of concentrations, for use with human plasma and other complex sample mixtures for diagnostic and therapeutic applications. The products from our PEARL [Pathogen-Encoded Adaptable Receptor Library] technology will yield antibody ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  2. New Drugs for Stress-related Affective Illness

    SBC: Azevan Pharmaceuticals Inc            Topic: NIMH

    DESCRIPTION (provided by applicant): Vasopressin (AVP) antagonists represent a novel therapeutic class for the treatment of depression. The potential utility of these compounds has emerged from observations in depressed individuals, findings in animal models, and an understanding of changes in hypothalamic-pituitary-adrenal (HPA) axis regulation under chronic stress. This Fast Track proposal seeks ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Design and development of a bioresorbable bone graft

    SBC: CarMell Therapeutics Corporation            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a safe, cost-effective, off-the-shelf, and well characterized bone filler material based on plastics derived from blood plasma. Over 800,000 bone procedures are performed in the US per year, and with the aging US population, this number will only continue to grow. However, current materials, including autografts ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  4. Surface Enhanced Biocompatible Blood Oxygenators

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative effects. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respi ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. MULTIPLEXED ASSAYS FOR AKT/M TOR PATHWAY- PHASE I SBIR TOPIC

    SBC: ROCKLAND IMMUNOCHEMICALS, INC.            Topic: NCI

    PTEN/Akt/mTORC 1and2 signal pathway is a critical regulator of cell survival, cell growth and proliferation, angiogenesis, cellular metabolism, cell migration and invasion and glucose uptake. A number of anticancer drugs in clinical trials are targeting this pathway. In Phase I, we will develop reliable, accurate, quantitative and sensitive multiplexed hybrid ELISA/qPCR assay (ELISA combined with ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Not Available

    SBC: ROCKLAND IMMUNOCHEMICALS, INC.            Topic: NCI

    Antibody therapy offers treatment for a wide range of diseases and can extend the life of cancer patients, but the treatment cost is extremely expensive. as patent protection of some current antibodies will expire in coming years, there is an opportunity to develop generic and lower priced versions of these therapeutic biologics for the treatment of cancer. To accelerate the development of a gener ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Synthetic Nanoparticle based Universal Influenza Vaccine

    SBC: IMMUNOTOPE, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Influenza viruses are highly infectious RNA viruses that cause epidemic respiratory disease in the human population. There is an urgent unmet need for an influenza vaccine with greater potency, durability of antibody response, and strain-cross reactivity that can be developed more rapidly than conventional influenza virus. The recent epidemic spread of H1N1 and ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. MULTIFUNCTIONAL NANOJACKETS FOR BREAST CANCER TREATMENT

    SBC: KEYSTONE NANO, INC.            Topic: NCI

    Keystone Nano, building on a successful partnership with Nalco and co-development programs with Johnson and Johnson, Eli Lilly, United Therapeutics, NanoTherapies, and the NCI, will develop multifunctional calcium phosphate NanoJackets for the simultaneous diagnosis and treatment of breast cancer. Despite advances in detection and treatment, breast cancer is still the second most common cancer amo ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. A novel fluorescent assay for ubiquitin isopeptide bond cleavage

    SBC: LIFESENSORS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): As the prominence of the ubiquitin and ubiquitin-like pathways increases the need for assays to measure the activity of the enzymes involved in these pathways grows. Currently the only high throughput methods for measuring ubiquitin and ubiquitin-like isopeptidase activity rely on non-physiological ubiquitin conjugates. The most widely used is Ub-AMC. In this a ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  10. Dissecting ubiquitin pathway selectivity with Ub-isopeptide microarrays

    SBC: LIFESENSORS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The network of enzymes involved in the ubiquitination (ligases) and deubiquitination (deubiquitinases or DUbs) of cellular proteins is one of the largest in the human proteome and plays a major role in the regulation of cellular homeostasis. This network interacts with other networks in the cell, especially the kinome, in regulating transcriptional activation a ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
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