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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two arm adaptive Phase II clinical trial to evaluate ONCa selective antagonist of the G protein coupled receptorGPCRdopamine receptor domainDRDin recurrent glioblastomaGBMand diffuse midline glioma associated with very poor prognoses and limited treatment optionsDRDis overexpressed in high grade gliomas and controls Akt ERK signaling pathwaysDownstream of target engage ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: Molecular Targeting Technologies, Inc.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. NDT of Fracture Toughness for Pipeline Steels

    SBC: Fbs, Inc.            Topic: 180PH1

    NDT of Fracture Toughness for Pipeline Steels 3/16/2018 Ultrasound-based technology to nondestructively determine fracture toughness of pipeline steels will be developed. Fracture toughness is the material parameter that, along with applied loading and flaw geometry, dictates the critical crack size, and therefore controls the flaw size that must be detected during inspections. A major challeng ...

    SBIR Phase I 2018 Department of Transportation
  4. Finding Human Carriers of Taeniasis to Prevent Neurocysticercois Associated Epilepsy

    SBC: APTAGEN LLC            Topic: ODCDC

    NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Doppler Wind Temperature Sounder

    SBC: Brandywine Photonics, LLC            Topic: 8212

    TECHNICAL ABSTRACT: We propose developing a new observational capability for measuring upper atmosphere (20-Km to 200-Km+ altitude) wind and temperature dynamics, based on Doppler imaging of Limb concentrations of NO, N2O, and CO2 called the Doppler Wind Temperature Sounder. The principle of operation is that by measuring the Doppler shift of trace gases created by the differential velocity betwee ...

    SBIR Phase I 2018 Department of CommerceNational Oceanic and Atmospheric Administration
  6. Topic 373: Monoclonal Antibodies to RNA-modifications

    SBC: Abzyme Therapeutics, LLC            Topic: NCI

    Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Piezoelectric Ring Mounted Oscillated Syringe System for Lower Distress, Lower Force, Laboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal Welfare

    SBC: ACTUATED MEDICAL, INC.            Topic: 200

    This Fast track SBIR developstestsand commercializes aPiezoelectric Ring Mounted Oscillated Syringe System for Lower DistressLower ForceLaboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal WelfareThe Oscillated Needle InserterONIis a simple one handedvascular access device that uses a novel vibratory piezoelectric ring to directly apply longitudinal microos ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. An Acoustofluidic Device for Biocompatible Platelet Separation

    SBC: Ascent Bio-Nano Technologies Inc            Topic: NHLBI

    Project Summary The ability to perform platelet separation with a high throughputhigh recovery ratehigh purityand high platelet integrity is extremely important in many biomedical research studies and therapeutic applicationssuch as platelet transfusionsCentrifugation is currently thegold standardlaboratory technique used to obtain platelets from whole bloodHoweverthis current approach for platele ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Computer Tool for Aiding in Accurate Assessment of Indeterminate Lung Nodules

    SBC: International Intelligent Informatics Solution Laboratory LLC            Topic: 101

    Low dose CT screeningLDCThas been approved by the Centers for Medicare andampMedicaid ServicesCMSfor Medicare coverageHoweverthe primary problem associated with CT is the high false positivedetectionsThis issue often leads to unpleasant and costly unintended consequencese gfollow up scans and or invasive biopsiesIn this projectwe propose to develop and commercializea novel computer tool to aid in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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