Award Data

Individual differences in vulnerability to sleep loss and fatigue from extended work hours and night work are a substantial problem in transportation work schedule development, fatigue risk management strategies, and prediction of performance impairment in real-world operations. This project will deliver an individualized Fatigue Management Program (FMP) technology for trucking operations that in ...

DESCRIPTION (provided by applicant): The product that will result from this SBIR program, proposed by Vironika and its consortium partner, The Wistar Institute, is a new (the first) small molecule drug candidate for Epstein-Barr virus (EBV) latent infection, and its associated pathologies. EBV is a prevalent human herpesvirus that has been classified by the World Health Organization as a human car ...

DESCRIPTION (provided by applicant): Fast and effective communication is the key to minimizing confusion, anxiety, and casualties both during and after a public health emergency. The ability of emergency services personnel to relay clear instructions, part icularly to vulnerable populations, results in better understanding of the situation by the population and faster compliance with these instruc ...

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DESCRIPTION (provided by applicant): The product that will result from this proposal will be a potent biological regulator of innate immunity, 1- peptidyl-2,3-diacylglyceride (PDAG), for use in the prevention of hospital-acquired (nosocomial) infections in highly-susceptible patient populations. Nosocomial infection is a rapidly growing cause of morbidity and mortality in U.S. hospitals and nosoc ...

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Motivating nurses' aids and nurse attendants is a challenge for nursing supervisors as is assuringWe will focus on providing tools to help assure the provision of quality care by these workers for epatients who are at risk for developing pressure ulcers. Monitoring the scheduled delivery of this cconventional means and poorer than expected clinical outcomes in many nursing homes reflect this prode ...

DESCRIPTION (provided by applicant): To reduce the incidence of pressure ulcers, administrators of long term care facilities must identify which care processes need improvement and measure if their management interventions are effective. Currently, this is difficult because the reliability of care delivery is overestimated in patients' charts and medical records. Most of the physical body care of ...

DESCRIPTION (provided by applicant): A Potential New Drug for Depression, an active SBIR Phase IIa award. The requested funds will allow additional characterization studies of three newly discovered mixed vasopressin 1a/1b antagonists, studies that were not part of the original application. These experiments will accelerate preclinical development of the novel mixed antagonists by facilitating i ...

The development of novel compounds that regulate specific subtypes of glutamate receptors for the treatment of CNS disorders is the major goal of Symphony Pharmaceuticals, Inc. Symphony discovered a novel series of heterocyclic 1,2-dihydrophthalazines that selectively antagonize AMPA receptors and protect animals in seizure models. Our hypothesis is that a 1 ,2-dihydrophthalazine AMPA receptor ant ...