Award Data

DESCRIPTION (provided by applicant): The objective of this Compact Membrane Systems (CMS) program is to develop a new platform technology for fire suppression and fire prevention systems around membrane supplied nitrogen enriched air (NEA). The limitation that the atmospheres used in the fire suppression be breathable to occupants in the proximity of a fire is easily accomplished by CMS technolog ...

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the single most common cause of death in the United States. Although the study of the CVD has greatly benefited from the use of gene-targeted transgenic mouse models, these small rodents do not accurately reflect human cardiovascular physiology. The Rabbit would be an excellent animal model for CVD research, considering its many ...

DESCRIPTION (provided by applicant): Experimental investigations have demonstrated that the delivery of HIFU (High Intensity Focused Ultrasound) to cancerous tumors results in the release of heat shock proteins and generates a beneficial immune response. T he release of proteins into the blood as a result of HIFU therapy is further demonstrated by the spike of the serum prostate specific antigen ( ...

DESCRIPTION (provided by applicant): Statins are the most prescribed drugs in the world. Their efficacy in primary and secondary prevention of cardiovascular disease as well as beneficial pleiotrophic and anti-inflammatory effects have fostered increasingl y aggressive usage and dosage. Their main clinically relevant safety risk is statin-induced myopathy (SIM) evidenced clinically as a constellat ...

DESCRIPTION (provided by applicant): Analyzing and processing free-text medical reports for data mining and clinical data interchange is one of the most challenging problems in medical informatics, yet it is crucial for continued research advances and impr ovements in clinical care. Natural language processing (NLP) is an important enabling technology, but has been held back because it is difficul ...

DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poo r protein solubility. This project seeks to develop a tool, a set of entropic bristle-based AquoProtTM vectors, to dramatically increase the fr ...

DESCRIPTION (provided by applicant): An estimated 18.2 million people (6.3 percent of the population) in the United States have diabetes; 90 to 95 percent of all diagnosed cases are type II diabetes (NIDDK, 2005). The search for new and more effective ther apies to address the growing number of Americans with type II diabetes and related conditions is currently hindered by the lack of a research a ...

DESCRIPTION (provided by applicant): The Phase II work proposed here involves the high-throughput proteome profiling of molecules associated with cardiovascular disease. Comparative profiling of disease-relevant species will lead to a marketable product - the PPM Cardiovascular Health and Wellness Report. Molecular profiling is accomplished using novel IMS-MS instrumentation and a three-minute an ...

DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) represents both a safeguard against the penetration of physiologically harmful substances into the central nervous system (CNS), as well as a considerable hurdle to the delivery of therapeu tic agents. A technology allowing safe, targeted, reversible opening of the BBB would potentially revolutionize both the study and treatment of ...

DESCRIPTION (provided by applicant): SHOT, Inc., in collaboration with the University of Minnesota (UofM), Indiana University School of Medicine (IUSoM) and IKOtech LLC, proposes research leading to a magnetic separation technology that provides an improve ment in potency and yield of pancreatic islets for transplantation. Islet transplantation is a method of treatment that has successfully revers ...