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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Precision Quality Check of Immunotherapeutics via Single Cell Cytokine Mapping

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    Despite the demonstrated benefit of CD targeted CAR T immunotherapeutics two challenges remain to bringing the therapeutics to market The first key challenge is to reproducibly manufacture the therapy so that the cellsandapos cytokine mediated function acts in a predictably consistent fashion post manufacturing The second key challenge is to manage the cellandapos s adverse effect immuno to ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DXDISCOVERY INC            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds II

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 300

    DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Leveraging advanced clinical phenotyping to enhance problem lists and support value-based healthcare

    SBC: VMT, INC.            Topic: NLM

    Project Summary As United States healthcare seeks to address inconsistent quality and overwhelming cost data and technology have become central to all suggested approaches With newly available electronic health data and massive growth in processing power the hardest challenges in using clinical data are becoming clear Big data holds the potential to enable personalized patient care population ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY This proposal aims to develop a therapeutic capable of preventing and treating the severe sinus inflammation associated with chronic rhinosinusitis CRS CRS is a debilitating inflammatory disease of the sinuses that impacts over million Americans and substantially diminishes the quality of life and productivity of affected patients From to the total US health care ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Glycosaminoglycans to Treat and Prevent Radiation Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    ABSTRACT Oral mucositis is a devastatingly painful inflammatory disease that frequently develops during cancer therapy and affects half a million people in the US The accompanying pain is so severe that patients often require narcotic pain medicines The clinical manifestations are ulcers in the mouth and gastrointestinal tract which are exacerbated by opportunistic infections Many patients al ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Point-of-care immunoassay for early diagnosis of pertussis

    SBC: DXDISCOVERY INC            Topic: R

    Project Summary Pertussis is rapidly re emerging as a serious public health threat in the United StatesDespite high vaccine coverage nationallyannual reported cases in the U Shave been increasing recentlywith ayear high ofinMoreoverreported cases represent a large underestimate of pertussis infectionsDiagnosis of early pertussiscatarrhal stageprior to paroxysmal coughis particularly challenging be ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Multi Source E Beam kV X Ray Tube for Image Guided Radiotheraphy

    SBC: Telesecurity Sciences, Inc.            Topic: 102

    DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. A microchip to analyze trafficking leukocytes in Alzheimer’s disease patients

    SBC: ISOPLEXIS CORPORATION            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most common neurodegenerative diseases that lead to detrimental outcomes such as progressive memory deficit and cognitive impairment Although it is expected that the prevalence of AD will double over the next years currently no widely accepted molecular biomarkers for early detection or non invasive monitoring ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Single-cell multi-protein device for informative cellular function evaluation

    SBC: ISOPLEXIS CORPORATION            Topic: 100

    DESCRIPTION provided by applicant ELISpot including its variant FLUOROSpot remains the mainstay to measure true secretion of single cells and to assess cellular function e g immunity in the pre clinical and clinical settings However because it measures only one or two proteins per single cell and provides minimal biological information it has limited utility for measuring cell biology an ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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