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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Public Rights-of-Way Assessment Instrumentation to Determine Accessibility

    SBC: BENEFICIAL DESIGNS INC            Topic: 081FH2

    City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

    SBIR Phase II 2010 Department of Transportation
  2. Development of novel tissue directed ultra sound therapeutic gene delivery system

    SBC: SONOGENE, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Low levels of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease (CHD). HDL cholesterol levels are predictive of major cardiovascular events in patients treated with statins. This relationship was also observed among patients with LDL cholesterol levels below 70 mg per deciliter. Studies have demonstrated that poly ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. NANOPHASE GLASS CERAMIC X-RAY IMAGING MATERIALS

    SBC: Materials Development, Inc.            Topic: NCI

    This Phase II focuses on moving a new transparent storage phosphor imaging plate technology from the laboratory to a clinical prototype product. In Phase I methods to make, polish, heat treat, and characterize ~6 x 8 cm glass plates that provide superior resolution compared to the current best were developed. Potential customers need better plates to improve imaging performance in CR systems and e ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Development of CMOS Based Large Format X-ray Detector for Protein Crystallography

    SBC: Research Detectors Incorporated            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop an inexpensive, yet very high quality detector system for protein crystallography, using Active Pixel Matrix CMOS (complementary metal-oxide-semiconductor) technology. We have based this effort on an existing CMOS imaging system for X rays, manufactured by Rad-icon Imaging Corporation. During Phase I of this proposed project, we increased ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Operant Behavioral Instrument for Measuring Trigeminal Neuropathic Pain in Rodent

    SBC: STOELTING COMPANY            Topic: NIDA

    DESCRIPTION (provided by applicant): Chronic pain remains a major burden on society, significantly affecting millions of people and costing the populace billions annually. Despite major advances made to our understanding of pain, very few new therapies have successfully translated to clinical care. A particular shortfall in this translation is the lack of a high-throughput, commercially available ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Automated technology for purification of active ingredients in natural products

    SBC: WRIGHTWOOD TECHNOLOGIES INC.            Topic: NCCAM

    DESCRIPTION (provided by applicant): The analysis of complex natural mixtures presents a significant scientific challenge in biomedical studies involving natural products and other complex biogenic samples, particularly when the need for isolation of minor constituents arises. Countercurrent chromatography (CCC) offers high loading capacity, complete sample recovery, and high purity fractions. It ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Metastatic bone cancer and multiple myeloma affects over 600,000 people every year in the United States and cause progressive bone destruction that results in severe pain, fractures, and the inability to walk. Patients usually present with incapacitating pain secondary to osseous involvement, with or without vertebral collapse, and to spinal cord and/or nerve r ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Non-invasive Assessment of Insulin Resistance

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this grant is to develop a non-invasive method for assessment of insulin resistance and impaired glucose tolerance (IGT) as a measure of pre-diabetes suitable for application to large-scale screening studies and to individualized preventive strategies in patients at risk for development of diabetes. This new approach is based on the kno ...

    SBIR Phase II 2009 Department of Health and Human Services
  9. Development Of A Next-Generation Thrombelastograph

    SBC: CORAMED TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Coramed is designing a next-generation point-of-care (POC) instrument, the TEG 6500, for monitoring patient hemostasis on demand. The instrument will introduce a completely new technology for monitoring clot formation and breakdown that is well suited for the continuum of settings from inside the hospital, to ambulatory care clinics, physician offices, and pati ...

    SBIR Phase II 2009 Department of Health and Human Services
  10. Software to Facilitate DNA Cloning

    SBC: GSL BIOTECH, LLC.            Topic: N/A

    DESCRIPTION (provided by applicant): DNA cloning, also known as gene splicing or recombinant DNA technology, underlies all of modern biomedical and biotechnology research. Yet DNA cloning frequently goes awry because this process involves a large number of variables, has many subtleties, and is hard to document with existing tools. DNA cloning is linked to a variety of other procedures, and resear ...

    SBIR Phase II 2009 Department of Health and Human Services
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