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DESCRIPTION provided by applicant Neurodegenerative diseases such as Alzheimer and other dementias present significant societal and economic burden The number of patients suffering from these disorders grows rapidly owing to the aging of the world population Alzheimerandapos s Association projects that the number of Americans living with Alzheimerandapos s disease AD will increase from ...

DESCRIPTION provided by applicant Advanced imaging technologies such as Positron Emission Tomography PET and Magnetic Resonance Imaging MR have led to remarkable improvement in our knowledge of brain metabolism function and biochemistry And yet our understanding of most neurological disorders is at best rudimentary Etiology of such common diseases as drug and alcohol addiction schiz ...

DESCRIPTION provided by applicant The goal of this Phase I Phase II fast track application is to develop and evaluate a simulation based product for training students and clinicians to develop the skills necessary to effectively apply Cognitive Behavioral Treatment CBT with patients with substance use disorders SUDs CBT is one of the most common and effective treatments for SUDs however ...

DESCRIPTION provided by applicant As new genetic analysis methods are developed rising emphasis is being placed on high quality sample preparation and the ability to obtain large quantities of high molecular weight and high purity DNA In DNA sequencing rd generation technologies offer long read lengths up to kb and require high quality isolated DNA In gene therapy and DNA vaccines high ...

DESCRIPTION provided by applicant Wireless Enhanced Myoelectric Control to Improve Upper Extremity Amputee Ability ABSTRACT The overall goal of our research program is to enable upper extremity amputees to be productive and independent For these individuals one of the most promising developments in the past decade has been the introduction of fully dexterous terminal devices However an effe ...

DESCRIPTION provided by applicant Sample preparation frequently presents a bottleneck for clinical molecular biology workflows and diagnostic tests Whereas there are many molecular detection modalities there are only a handful of automated sample preparation workflow strategies Existing instruments that are built around these sample preparation strategies and chemistries range in cost from $ ...

DESCRIPTION provided by applicant MiRNA have the potential to revolutionize both cancer detection and therapeutics as they exert control over nearly every cellular process from differentiation to growth and senescence Although over miRNA are predicted to exist studies have suggested that smaller subsets of only miRNA are often the critical players in any specific disease or cellular ...

DESCRIPTION provided by applicant Transcutaneous ultrasound imaging is becoming an increasingly widespread tool across a wide range of clinical specialties partly encouraged or even mandated by federal guidelines However the imaging skill and manual dexterity necessary to perform these procedures is not easy to acquire and pose a significant challenge to efficient and effective procedures f ...

DESCRIPTION provided by applicant Ninety five percent of colorectal cancer develops by a well understood series of genetic mutations over a year time frame beginning as a tissue growth commonly termed a polyp Approximately one third to one half of adults will develop one or more polyps over their lifetime approximately ten percent of which will progress to colon cancer Therefore the o ...

DESCRIPTION provided by applicant This project will complete development efforts toward commercialization of multilineage point of care Lassa fever diagnostics Lassa fever LF is a severe often fatal viral hemorrhagic fever VHF Because of its high case fatality rate ability o spread easily by human human contact and potential for aerosol release Lassa virus LASV the causative agent ...