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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Mechanism underpinning synergy with combined treatment of MTI-101 and Dexamethasone in Multiple Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: NCI

    ABSTRACT Multiple myeloma (MM) is the second most common hematopoietic cancer and while survival rates have slowly increase in the last 10 years, the five-year survival is just over 50%. The high number of patients that become refractory to current therapies is the core reason for the low long-term survival. Therefore, there is a crucial need to develop unique drugs that are active in refractory a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. PDE4D PET Ligand

    SBC: Tetra Discovery Partners, Inc.            Topic: 101

    Tetra Discovery Partners was the recipient of an NIH Blueprint Neurotherapeutics Network award to develop a phosphodiesterase-4D (PDE4D) allosteric inhibitor for treating cognitive impairment in patients affected by psychiatric and neurologic diseases. The Tetra-NIH Blueprint drug, BPN14770, currently is in human Phase 2 clinical trials for the treatment of Fragile X Syndrome and Alzheimer’s dis ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIEHS

    Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Large Pore SPP Particles for Protein Separations

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    AbstractLife sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution high performance liquid chromatographicHPLCseparations of larger molecules including proteinspeptidesglycopeptidesand glycansProteins therapeutics are complex moleculessusceptible to intended or unintended alterations of composition and conformationMany therapeutic ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Bactericidal Intravascular Biosensor for Continuous Reading of Lactate in the lCU Ph2

    SBC: BIOCREDE INC.            Topic: 300

    PROJECT SUMMARYABSTRACT In Phase IBiocrede developed a wirelessFrflexibleand aFrdual lumencatheternitric oxideNOreleasingin vivo tested without heparin injectionscontinuous lactate sensor that can wirelessly monitor intravenousIVblood lactate levels to alert caregivers in the ICU when lactate levels riseElevated blood lactate levels are associated with major morbidity and mortality in critically i ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Commercial Software Using High-throughput Computational Techniques to Improve Genome Analysis

    SBC: Genomenon, Inc.            Topic: 172

    Recent advances in DNA sequencing technology have not been matched by improved analytic techniques to quickly and accurately interpret patient genome data to inform diagnosisprognosis and therapy making decisions in the clinic and to identify candidate biomarkers of disease in research laboratoriesDevelopment of automated techniques to facilitate interpretation of this data will benefit patient ca ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY Chronic rhinosinusitis (CRS) is one of the most prevalent inflammatory diseases in the U.S., affecting up to 16% of the population and substantially diminishing the quality of life and productivity of patients. In four years, the annual U.S. health care expenditure to treat patients with CRS dramatically increased from $9B to $64B (5% of the health care budget), with a correspondin ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Improving drug safety for pregnant women by delivering current and authoritative information via mobile devices

    SBC: RightAnswer.Com, Inc.            Topic: NCBDDD

    Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

    SBIR Phase II 2018 Department of Health and Human ServicesCenters for Disease Control and Prevention
  9. Public Rights-of-Way Assessment Instrumentation to Determine Accessibility

    SBC: BENEFICIAL DESIGNS INC            Topic: 081FH2

    City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

    SBIR Phase II 2010 Department of Transportation
  10. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion

    SBC: ALPHACORE PHARMA, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The hallmark of atherosclerosis is the accumulation of cholesterol in arteries, resulting in plaque which can lead to a heart attack (myocardial infarction (MI)). The excess cholesterol causes inflammation, promotes plaque instability, and in later stages, narrows the vessel lumen to obstruct blood flow. Normally, cholesterol is removed from arteries and deli ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
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