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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Public Rights-of-Way Assessment Instrumentation to Determine Accessibility

    SBC: BENEFICIAL DESIGNS INC            Topic: 081FH2

    City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

    SBIR Phase II 2010 Department of Transportation
  2. Design and development of a bioresorbable bone graft

    SBC: CarMell Therapeutics Corporation            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a safe, cost-effective, off-the-shelf, and well characterized bone filler material based on plastics derived from blood plasma. Over 800,000 bone procedures are performed in the US per year, and with the aging US population, this number will only continue to grow. However, current materials, including autografts ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Methyltransferase Drug Discovery

    SBC: REACTION BIOLOGY CORPORATION            Topic: NCI

    DESCRIPTION (provided by applicant): Chromatin assembly and structure is highly regulated during DNA replication, gene expression, and progression through the cell cycle. Dysfunctions of epigenetic factors, including methylation states, are associated with a variety of cancers. Histone methyltransferases (HMTs), including lysine and arginine methyltransferases, are considered a new and important c ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Developing a Noninvasive Method and Device for Assessing the Degree of Midperiphe

    SBC: NEURO KINETICS, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): The long-term objective of this application is to develop an imaging device for the early detection, diagnosis and quantification of the degree of midperipheral retinal ischemia in Diabetic Retinopathy (DR). Earlier diagnosis of DR could facilitate intervention at a stage that may prevent or lessen permanent damage from the ravages of the disease, in turn, impr ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Biomarker for Cognitive Impairment in Chronic Alcoholism

    SBC: PHFR, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Previous work has identified a subgroup of chronic alcoholism subjects with severe, generalized cognitive impairment and a very poor outcome. What is critically lacking are brain molecular biomarkers that antedate both the cognitive impairment and the earliest, most minimal brain structural changes. Given the increased morbidity associated with cognitive impair ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Low Insertion Force Epidural, LIFE System for Controlled Insertion

    SBC: ACTUATED MEDICAL, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant: In this Phase II NIH SBIR, the Low Insertion Force Epidural (LIFE) device will be further optimized and efficacy measured on human cadavers and live porcine models. Piezo Resonance Innovations, Inc. successfully designed and demonstrated the Phase I LIFE device insertion tool in various tissue models, including trials by senior anesthesiologists. The Phase II de ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. College Outcomes Management System (COMS) Phase 2

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: NIDA

    DESCRIPTION (provided by applicant): The prevalence and severity of mental health and chemical dependency disorders on college campuses have reached crisis levels. A national survey of 29,230 college students in 2002 found that, at some point during the previous year, 45 percent had felt so depressed that they could not function; 65 percent had felt things were hopeless. Chemical dependency is w ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. A Novel Antimicrobial Mimetic for Oral Candidiasis

    SBC: PolyMedix, Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Oral infections of Candida albicans represent an increasing problem in human health. In immunocompromised individuals, especially those suffering from AIDS, candiasis can result in both localized, yet painful lesions in the oral cavity as well as life-threatening systemic infections. Furthermore, due to the use of standard antifungal treatments, an increasing n ...

    SBIR Phase II 2010 Department of Health and Human Services
  9. Molecular screen for isopeptidase inhibitors to treat pulmonary disease

    SBC: Progenra, Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): With the approval of the proteasome inhibitor Velcade for multiple myeloma therapy, the ubiquitin pathway has been validated for drug discovery. An alternative ubiquitin-associated degradation pathway is lysosomal; for example, the ubiquitin E3 ligase Cbl promotes degradation of membrane bound epithelial growth factor receptor (EGFR) by ubiquitylating the recep ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. Efficient Implementation of A New and Accurate DFT Method

    SBC: Q-CHEM, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Density functional theory (DFT) is perhaps the most widely applied quantum chemistry method in molecular simulations due to its ability to accurately and efficiently model a wide range of molecular systems. Still, it has a major deficiency, namely the lack of nondynamic correlation. As a result, it can yield unreliable results for chemical reactions, radicals, ...

    SBIR Phase II 2010 Department of Health and Human Services
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