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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Public Rights-of-Way Assessment Instrumentation to Determine Accessibility

    SBC: BENEFICIAL DESIGNS INC            Topic: 081FH2

    City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

    SBIR Phase II 2010 Department of Transportation
  2. New Reagents for Synthesis of High Potency siRNA

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): New Reagents for Synthesis of High Potency siRNAs Abstract Since the discovery of short interfering RNA (siRNA) molecules in the late 1990s, siRNA technology has developed rapidly as a powerful tool for functional genomic analysis, target validation and therapeutic purposes. However, the potency and persistence of unmodified siRNAs is dramatically limited by th ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Amplification Strategies for Detection of Fragile X Gene Trinucleotide Repeats

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 5'-untranslated region of the FMR1 gene. FXS affects 1/4000 men and 1/6000 wo ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Unique Anti-microbial Rinse to Reduce Oral Inflammation

    SBC: Biomedical Development Corporation            Topic: NHLBI

    DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, and stroke), and diabetes, as well as for pregnancy complications such as preterm birth. It is well established that periodontal disease results ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Instrument System and Technique for Minimally Invasive Periodontal Surgery (MIS)

    SBC: DENTAL DESIGNS OF DALLAS            Topic: NIDCR

    DESCRIPTION (provided by applicant): The Phase II project entitled Instrument System and Technique for Minimally Invasive Periodontal Surgery (MIS), is designed to (1) further develop the instrument system created in the Phase I effort and (2) demonstrate the clinical efficacy of the instrument system and MIS in a clinical study. Two instrument technologies were developed during the Phase I effort ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Preclinical development of WP1066, an effective inhibitor of STAT3 activation for

    SBC: HOUSTON PHARMECUTICAL INC            Topic: NIAID

    DESCRIPTION (provided by applicant): Lack of effective therapeutics for CNS malignancies led to our long term scientific interest in brain cancers and to our previous discoveries and preclinical development of two other small molecules of distinctly different classes (a topoisomerase II inhibitor-WP744 and an inhibitor of tumor cell metabolism-WP1122) specifically directed at the treatment of CNS ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. Laser Tissue Welding compared to Radio frequency ablation for surgical treatment

    SBC: Laser Tissue Welding, Inc            Topic: NCRR

    DESCRIPTION (provided by applicant): Long term objectives Laser Tissue Welding, Inc. (LTW) focuses its research and product development in areas of innovative sutureless laser tissue welding using biodegradable and biocompatible biomaterials to join, repair and seal tissues for controlling the leakage of a wide variety of fluids including blood, gastrointestinal fluids, urine, bile, lymph, and eve ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Targeted Neural Plasticity for the Treatment of Tinnitus

    SBC: MICROTRANSPONDER, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): In Phase I, we demonstrated the feasibility of using VNS stimulation paired with tone presentations to completely reverse the effects of tinnitus in a rat model of the disease. The Specific Aim of Phase II is to accumulate data for the submission of an IDE application for testing the safety and efficacy of our therapeutic VNS device in humans. Approximately ...

    SBIR Phase II 2010 Department of Health and Human Services
  9. Computational Methods for Functional Genomic Discovery from Gene Knockout Studies

    SBC: SERALOGIX, LLC            Topic: NHGRI

    DESCRIPTION (provided by applicant): The overall Phase II objective is to continue the development/validation of new system biology computational tools for inferencing gene regulatory relationships from gene expression data obtained from multi-perturbation gene knockout experiments. NIH's Knockout Mouse Project (KOMP) is an initiative to generate a public resource of mouse embryonic stem (ES) cell ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. High performance micromachined microphones for hearing aids

    SBC: SILICON AUDIO, LLC            Topic: NIDCD

    DESCRIPTION (provided by applicant): Overall, client satisfaction with hearing-aid systems is very low. Today, only 2 percent of Americans wear a hearing aid, while it is believe that at least 10 percent of Americans could benefit from a hearing assistive device. Innovations at the microphone level have a direct positive impact on hearing aid performance. This work is focused on commerci ...

    SBIR Phase II 2010 Department of Health and Human Services
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