Award Data

City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

DESCRIPTION (provided by applicant): In our Phase 1 application, we described an endothelial specific receptor, Robo4, that is expressed in mature vessels and is upregulated following endothelial injury. Robo4, following activation by its protein ligand, Slit2, reduces agonist induced vascular leak in vitro and in vivo. We provided evidence of Slit2's efficacy in animal models of acute lung injury ...

DESCRIPTION (provided by applicant): The goal of this program is to create an implantable stimulator device to restore functional eye blink in patients with unilateral facial nerve paralysis. The system will electrically stimulate the paretic eyelid when EMG electrodes detect normal blink from the contralateral eye to produce a synchronous blink. The implant will consist of a thin, ceramic package ...

DESCRIPTION (provided by applicant): In our Phase I application, we proposed that blocking HTRA1 with antibodies might be an effective strategy for treating age related macular degeneration. We tested this hypothesis by a) generating monoclonal antibodies against HTRA1 and b) determining whether a monoclonal antibody would be effective in models of vascular eye disease. We have accomplished each o ...

DESCRIPTION (provided by applicant): Many human diseases-if not all human diseases-and human health appear to be linked to our genetics. Major government and private research efforts are focused on investigating this linkage. Unfortunately, one of our best tools for this critical work-i.e., microarrays-holds us back, as most provide only generally qualitative results, limiting their usefulness. O ...

DESCRIPTION (provided by applicant): A novel, venous window access device (VWAD), anastomotic tool, and minimally invasive, image-guided surgical procedure to provide hemodialysis for patients suffering from End Stage Renal Disease (ESRD) have undergone early stage development. The device can serve as a destination therapy or as a bridge device to provide temporary access during maturation of an ...

Location 1860 WENDY WAY RENO, NV 89509 United States N44CO200900040 $749 996.00 2 009 PHASE II TOPIC 233: AUTOMATED PROCESSING OF CANCER-RELATED DATA Department of Health and Human Services SBIR PHS2009-1 QUANTUMMARK LLC Phase II N44CO200900040 1 ...

DESCRIPTION (provided by applicant): The overarching aim of this innovative proposal is to develop and then commercialize a non-invasive topical product which is safe and easy to administer that treats severe uveitis, including intermediate and posterior uveitis. Uveitis is the third leading cause of blindness in the United States. Heretofore, the primary treatments of intermediate and posterior u ...