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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A single-cell device to capture and analyze rare T-cells from solid tumors.

    SBC: IsoPlexis            Topic: 102

    Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Precision quality check of immunotherapeutics via single-cell cytokine mapping

    SBC: IsoPlexis            Topic: 102

    Adoptive transfer of autologous T cells engineered to express chimeric antigen receptorsCARshas emerged as a promising immunotherapy for patients with hematologic malignanciessuch as CDCARs in leukemias and lymphomasHoweverchallenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell productsince infused cellsasliving drugscan be activated and release a varie ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics

    SBC: IsoPlexis            Topic: 100

    With this PhasesubmissionIsoPlexis proposes to deliver a single cell proteomic solution for ultra sensitive detection of unique correlative biomarkers in pre clinical mouse modelsin an automated system that can be used to accelerate the discovery of potential immune therapeuticsThe recent revolution in new basic science discovery is failing to translate into improved patient treatmentThe reduction ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease

    SBC: IsoPlexis            Topic: NIBIB

    MyelofibrosisMFbelongs to a group of closely related chronic blood diseasesmyeloproliferative disordersMPDMost MF patients have no symptoms or present with nonspecific constitutional symptomsweight lossfatigueas such an early stage diagnosis of MF is challengingMF is clinically suspected when patients present with an enlarged spleen and or with anemiathrombocytopeniaor leukopenia leukocytosishowev ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Public Rights-of-Way Assessment Instrumentation to Determine Accessibility

    SBC: BENEFICIAL DESIGNS INC            Topic: 081FH2

    City planners and engineers need detailed assessments of public rights-of-way to evaluate existing conditions, determine compliance with draft accessibility guidelines, and plan reconstruction projects. Current assessment methods are inadequate and inefficient due to the time and resources required. This project will develop an automated public rights-of-way assessment process and the measuremen ...

    SBIR Phase II 2010 Department of Transportation
  6. PHASE II TOPIC 233: AUTOMATED PROCESSING OF CANCER-RELATED DATA

    SBC: QUANTUMMARK LLC            Topic: N/A

    Location 1860 WENDY WAY RENO, NV 89509 United States N44CO200900040 $749 996.00 2 009 PHASE II TOPIC 233: AUTOMATED PROCESSING OF CANCER-RELATED DATA Department of Health and Human Services SBIR PHS2009-1 QUANTUMMARK LLC Phase II N44CO200900040 1 ...

    SBIR Phase II 2009 Department of Health and Human Services
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