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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY Chronic rhinosinusitisCRSis one of the most prevalent inflammatory diseases in the U Saffecting up toof the population and substantially diminishing the quality of life and productivity of patientsIn four yearsthe annual U Shealth care expenditure to treat patients with CRS dramatically increased from $ B to $Bof the health care budgetwith a corresponding rise in surgical treatment ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN: A Phase II Clinical Trial in Adolescents/Young Adults (AYA)with CNS Malignancies

    SBC: DEKK-TEC INC            Topic: 102

    AbstractThe goal of this Phase II clinical trial application will be to evaluatedemethylcholesteryloxycarbonylpenclomedineDM CHOC PENas anticancer therapy for adolescents and young adultsAYAwith cancer involving the brain in a Phase II clinical trialDM CHOC PENFigis a polychlorinated pyridine cholesteryl carbonateFigthat is lipophilicelectrically neuralis able to cross the blood brain barrierBBBlo ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Novel SCD1 inhibitors for treatment of cancer

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

    STTR Phase II 2018 Department of Health and Human Services
  4. Development of PEGylated MTI-101 for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACTModulation Therapeutics is developing a first in class cyclic peptide coined MTIfor the treatment of multiple myelomaThe company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and EuropeModulation Therapeutics is now poised to further advance this class of compound ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Wafer-Level Electronic-Photonic Co-Packaging

    SBC: Phase Sensitive Innovations, Inc.            Topic: AF16AT01

    In phase II work, we will collaborate with Prof. Stefan Preble in RIT and continue to develop large scale hybrid integration and packaging techniques for key active photonic components such as lithium niobate on insulator (LNOI) modulators and modified uni-traveling (MUTC) photodiodes. We will demonstrate a low V, broadband, small footprint LNOI modulator with hybrid Si/LN or SiN/LN waveguide usin ...

    STTR Phase II 2018 Department of DefenseAir Force
  6. Dynamic and Efficient Vapor Compressor

    SBC: BASCOM HUNTER TECHNOLOGIES, INC.            Topic: AF171057

    This Air Force SBIR project will develop and demonstrate a refrigerant vapor compressor that can provide up to 150 kW nominal cooling capacity.The developed compressor will be dynamically responsive to the needs of the vapor cycle system and can sustain high efficiency while providing cooling over the entire range of operating conditions for next generation aircraft.

    SBIR Phase II 2018 Department of DefenseAir Force
  7. Dynamic and Efficient Vapor Compressor for Aircraft Thermal Management Systems (TMSs)

    SBC: S-Ram Dynamics, LLC            Topic: AF171057

    S-RAM Dynamics (S-RAM) will design, fabricate, test, and commercialize a high-performance axial piston transcritical CO2 energy recovery compressor (ERC) to support next-generation aircraft thermal management systems for the U.S. Air Force and commercial applications

    SBIR Phase II 2018 Department of DefenseAir Force
  8. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIEHS

    Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Evaluation of oral oleocanthal to prevent and/or treat Alzheimer's disease and related dementias

    SBC: Oleolive, LLC            Topic: NIA

    PROJECT SUMMARY Alzheimer s diseaseADis a progressive neurodegenerative disorder of the elderly that afflicts aboutmillion patients globally and overmillion Americans in the USDespite the considerable research effort to preventtreator cure the diseaseeffective strategies remain lackingThe accumulation of amyloidAin the brain blood vessels can result in the development of cerebral amyloid angiopath ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Large Pore SPP Particles for Protein Separations

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    AbstractLife sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution high performance liquid chromatographicHPLCseparations of larger molecules including proteinspeptidesglycopeptidesand glycansProteins therapeutics are complex moleculessusceptible to intended or unintended alterations of composition and conformationMany therapeutic ...

    SBIR Phase II 2018 Department of Health and Human Services

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