Award Data

Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

The goal of this development effort is to provide warfighters with inexpensive methods to view geospatial intelligence information on a hand-held tablet through their sense of touch. This allows eyes-free and silent operation without generating light. This proposal deals with two surface haptic display technologies. Variable-friction displays create haptic effects by varying the coefficient of fri ...

Technical Abstract (200 word limit): While state-of-the-art microbolometers demonstrate impressive capabilities for low-cost uncooled long-wavelength infrared (LWIR) imaging, there is currently a need for low-cost, mid-wavelength infrared (MWIR) imaging systems capable of high performance with fast frame rates at high operating temperatures. HgTe colloidal quantum dot (CQD) focal plane arrays (FPA ...

To reach the end user, oil and gas production at the wellhead must be transmitted through the country and distributed to a wide range of customers. This logistical system requires natural gas gathering lines, processing facilities, product storage tanks and lots of other equipment. What results is air pollution caused by industry losses during these operations and the use of continuous or intermit ...

Nonsense Suppressing Drugs for Rett Syndrome Rett syndromeRTTis a devastating genetic condition that affects mostly femalesIt is one of the worst types of neurodevelopmental disordersthe affected girls are born without any obvious problemsdevelop in a seemingly typical manner for the first year of lifebut then abruptly and without warning lose most of their acquired abilitiesRTT girls then typical ...

SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

Glycan modifications of natural products are increasingly important in the discovery of new pharmaceuticalsWhile glycodiversity gives rise to important therapeutic properties of bioactive moleculesexploring glycodiversity has challengesIsolating glycosylated compounds from nature is often difficult due to low concentrations and the presence of multiple related molecules with similar structures and ...

PROJECT SUMMARYThe purpose of the proposed project is to combine wideband acoustic immittanceWAIand middle ear muscle reflexMEMRtesting using new approaches that improve sensitivityincrease test efficiencyand provide objectivity in interpretationAcoustically elicited MEMRs have a long history of value in the clinical evaluation of hearing lossWhile sensitive to and affected by middle ear disorders ...

PROJECT SUMMARY Diabetic retinopathyDRis a complication of diabetes and a leading cause of blindness in the worldAlthough it is widely accepted that DR is driven by ischemiathe current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR or angiogenesis in proliferative DRAs a resultmost patients have alrea ...