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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 373: Exonuclease Time-of-Flight for the Low-Cost, Rapid Identification of Methylated RNA Single Molecules

    SBC: Digital Nanogenetics LLC            Topic: NCI

    There is growing interest in the study of RNA modifications and its potential role(s) in many physiological abnormalities, such as modulating many processes associated with cancer development and progression. While RNA sequencing (RNA-seq) using short-read nextgeneration sequencing (NGS) have proven to be a useful tool for identifying specific RNA modifications, there still remains technical chall ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Device for Rapid, Complete & Durable Occlusion of Wide-Neck Cerebral Aneurysms

    SBC: Metactive Medical, Inc.            Topic: 106

    ABSTRACT Metactive Medical is developing the Ballstent Microcatheteran innovative medical device for the endovascular embolic treatment of cerebral aneurysmswhich are a common cause of strokeThe key component of the device is the Ballstentan expandabledetachablegold metal balloon that can be pleated and folded at the distal end of a delivery microcatheteradvanced into an aneurysm sac over a guidew ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Over-the-Wire Device for Immediate and Complete Peripheral Artery Occlusion

    SBC: Metactive Medical, Inc.            Topic: NHLBI

    ABSTRACT Metactive Medical is developing the Blockstent Microcatheteran innovative medical device for endovascular occlusion of peripheral arteries and veinsThe device uses an expandabledetachablegold metal balloon that can be delivered using a highly flexiblelow profileover thewire microcatheteraddressing an unmet medical need for a device that is easy to use and delivers immediatecompleteand las ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Generation of High Resolution Antibody Mimetics to Improve the Visualization of Subcellular Structures by Super Resolution Microscopy

    SBC: Nectagen, Inc.            Topic: 400

    The goal of this Phase I SBIR project is to develop a set of high resolution antibody mimeticsnanoCLAMPsoptimized for super resolution imaging of a broad range of subcellular structuresAdvances in super resolution microscopy have enabled the achievement of resolutions well below the diffraction limit with current techniques now approachingnmFor immunostainingthenm size of antibody complexes now li ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Affinity reagents for the sub-fractionation of specific exosomal populations

    SBC: Nectagen, Inc.            Topic: 400

    The goal of this Phase I SBIR project is to develop affinity reagents useful for the sub fractionation of specific exosomal populationsBecause exosomal makeup and cargo reflect the typedevelopmental stageand the disease state of the cells they are shed fromthey are attractive targets for non invasive diagnosticsExosomes are also being investigated for therapeutic applications such as vaccines and ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY Chronic rhinosinusitisCRSis one of the most prevalent inflammatory diseases in the U Saffecting up toof the population and substantially diminishing the quality of life and productivity of patientsIn four yearsthe annual U Shealth care expenditure to treat patients with CRS dramatically increased from $ B to $Bof the health care budgetwith a corresponding rise in surgical treatment ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIEHS

    Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Determination of protective efficacy of multimeric Shigella vaccine as the next step toward human trials

    SBC: Hafion LLC            Topic: NIAID

    SUMMARYShigellosisbacillary dysenteryis a severe bloody diarrhea that occurs worldwide and for which there is no licensed vaccineThis disease is particularly devastating in low income regions of the world where clean water and proper sanitation are lackingMortality and morbidity are highest in children under the age ofwith survivors exhibiting impaired growth due to malnutritionShigella sppare als ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Targeting Bioenergetic Flux for Alzheimer's Disease Management

    SBC: Aerobyx LLC            Topic: NIA

    PROJECT SUMMARYBioenergetic dysfunction occurs in Alzheimer s diseaseADand represents a potential AD therapeutic targetFor these reasonswe founded AerobyxLLCThe goal of Aerobyx is to develop drugs that specifically target brain bioenergetic fluxesand to use those drugs to treat persons with ADOur strategy emphasizes fundamental biochemical principles such as the law of mass actionand additionally ...

    SBIR Phase I 2018 Department of Health and Human Services

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