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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY Chronic rhinosinusitisCRSis one of the most prevalent inflammatory diseases in the U Saffecting up toof the population and substantially diminishing the quality of life and productivity of patientsIn four yearsthe annual U Shealth care expenditure to treat patients with CRS dramatically increased from $ B to $Bof the health care budgetwith a corresponding rise in surgical treatment ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development of a DCLK1 siRNA Nanoparticle as Targeted Therapy to Treat Pancreatic Cancer

    SBC: COARE Holdings, Inc            Topic: NCI

    AbstractPancreatic ductal adenocarcinomaPDACis one of the most devastating human cancersIt is the fourth leading cause of cancer related deaths in the U Sannuallywith a andltyear survival rateDespite FDA approved therapeutic regimens and marked improvements in medical and surgical careno significant impact on PDAC patient survival has been achievedInsomeAmericans are expected to be diagnosedandare ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIEHS

    Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Development of a User-friendly Bayesian Software Package: Proof of Concept

    SBC: Bayesic Technologies, LLC            Topic: 400

    PROJECT SUMMARY Essentially all researchers use statistical methods to determine whether observed results provide evidence to support their hypothesis or could be due to chance aloneFunctionality and ease of use are key factors dictating researcherschoice of statistical softwareSoftware packages using frequentist statistics have dominated the marketplaceCurrent trends in software development inclu ...

    STTR Phase I 2018 Department of Health and Human Services
  6. PET Imaging Agent for Myocardial Infarction

    SBC: HEXAKIT, INC.            Topic: NHLBI

    Project Summary Each year millions of individuals suffer from myocardial infarctionMIor heart attackDiagnosis of MI is dependent on a complex set of tests which include imagingcardiac troponin levels in plasmaand electrocardiogramViability assessment and myocardial perfusion imaging by radiolabeled tracers has the most impact on the diagnosis and risk assessment of MIHoweverperfusion scans are una ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Multi-release drug-coated balloons for the treatment of peripheral artery disease with long, diffuse, and multiple lesions

    SBC: Tailored Medical Devices Inc.            Topic: NHLBI

    Project Summary Abstract Peripheral artery diseasePADaffects overmillion people worldwide and can result in life threating complicationsCurrentlydrug coated balloonsDCBsare used to treat lesions in the peripheral arteriesHowevercommercially available DCBs are designed to treat only a single blockage siteIn PAD patientscomplex lesions involving longdiffuseand or multiple blockages are often found r ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Novel SCD1 inhibitors for treatment of cancer

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

    STTR Phase II 2018 Department of Health and Human Services
  9. Pre-IND development of CBT-15 monoclonal antibody therapy against renal cell cancer

    SBC: COARE Holdings, Inc            Topic: 102

    AbstractRenal cell cancerRCCis a devastating cancer with a very lowyear survival rate for patients who present with local or distant spreadRCC has stunning resistance to radiotherapy and chemotherapyrampant epithelial mesenchymal transitionEMTas well as a hypoxic microenvironmentall factors indicative of cancer stem cellsCSCsMany lines of treatment have been trialed against RCC with positive resul ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery

    SBC: IsoPlexis            Topic: 105

    In this Phase I application IsoPlexis proposes to deliver a novel method for targeted profiling of both the transcriptome and secretome from an array ofsingle central and peripheral immune cellsSpecificallywe will deliver a single cellmRNA and secreted protein capture assay with proven sensitivity for detecting the most important predictive biomarkers for neurodegenerative diseasesThere is growing ...

    SBIR Phase I 2018 Department of Health and Human Services

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