Award Data

To reach the end user, oil and gas production at the wellhead must be transmitted through the country and distributed to a wide range of customers. This logisticalsystem requires natural gas gathering lines, processing facilities,product storage tanks and Jots of other equipment. What results is air pollution caused by industry losses during these operations and the use of continuous or intermitte ...

Obesity is associated with an increased risk of a number of chronic and progressive diseases and obesityrelated metabolic diseases constitute a significant public health burdenThe increased likelihood of developing insulin resistance and diabetes is probably the most commonly recognized risk of being obeseIn additionobesity is also associated with accumulation of lipid in the liver parenchymahepat ...

Project Abstract Summary The goal of this STTR application is to deliver a brain MRI technology that feeds back head motion measurements derived from our Framewise Integrated Real Time MRI MonitoringFIRMMto MRI scan participants in order to reduce head motion via behavioral trainingBecause MRI scanning produces highresolution images and does not expose patients to radiationit has become an immense ...

Mitofusin agonists to prevent Charcot Marie Tooth diseaseA Gerald W Dorn IIMD Mitochondria in MotionIncWashington University in St Louis School of Medicine AbstractCharcot Marie ToothCMTdisease typeA is an incurableprimarily pediatricautosomal dominant neuromuscular degenerative disease caused by mutations in the mitofusinMFNgeneThere are currently no disease altering treatmentsMitochondria in Mot ...

Project Summary Opioid use disorderOUDhas reached epidemic levels in the United Stateswith catastrophic resultsmore Americans died from opioid overdoses inandthan in the entirety of the Vietnam WarPrimary care providersPCPsserve a critical role in combatting this epidemicbecause they see patients who misuse opioids but are not yet dependent in addition to those who are already dependentHoweverther ...

The proposed developmental activity will result in a humanized monoclonal antibody, Tiptuhumab, which acts as a radiomodulator/immunotherapeutic. This antibody targets the cancer neoantigen, Tax Interacting Protein-1 (TIP-1), and is cytotoxic to non-small-cell lung cancer cells, NSCLC. For patients with NSCLC, the 5-year overall survival rate is 14.9% with a median survival time of 4 months. The c ...

With this phase I submissionIsoPlexis proposes to deliver comprehensive profiling of the immune system as a measure of age dependent health in response to medical challenges or traumaThis assay will connect signaling events in the metabolome and proteome from thousands of single cells in parallel enabling the simultaneous tracking of metabolic activity and protein signaling within each immune cell ...

Abstract The objective of this project is to develop a multi dose safety profile for a novel drug candidate to treat a devastating neurodegenerative disease called Spinal Muscular AtrophySMASMA is an autosomal recessive disorder that is the leading genetic cause of infantile deathoccurring inlive birthsThe gene responsible for SMA is called survival motor neuronSMNSMNis nearly identical to SMNhowe ...

Our innovative 3D Motion Analysis technology allows for fast and efficient screening of running technique in military personnel that has previously not been available to this scale. We propose providing education and training on our portable 3D Motion Analysis technology to military personnel to explore new ways to utilize this technology. The education and training will focus on ways to identify ...

Smart Diagnostics Systems has successfully developed a diagnostic system, which utilizes sensor particle reagents, a detection instrument, and software to rapidly and accurately identify the presence of dangerous or harmful analytes in food, water, and environmental sources. SDS’s developed detection system reduces total testing time by 80% (4-6 hour total detection time), eliminates false ...