Award Data

The objective of this project is to develop a test-validated CAD tool for performing virtual laser shock peening(LSP) simulations of rotorcraft components. Virtual LSP peening can be used, in conjunction with virtual fatigue testing, to conduct simulations to assess the effects of variations in process parameters, i.e., laser beam power density and size, number of layers, and the overlay pattern ...

The Air Force Research Laboratory (AFRL), Military Satellite Communication (MILSATCOM), and National Aeronautics and Space Administration (NASA) have a current and future need for advanced commercially available inherently radhard primitive cell libraries to support new designs for satellites and other spacecraft. American Semiconductor Inc. proposes the use of double gated Flexfet technology for ...

We propose to continue the development of rapid, handheld multiplexed assays for the detection of biological warfare agents and an associated handheld automatic reader. We will rigorously evaluate the 5-target assay developed in Phase I, and develop an 8-target multiplex during this Phase II project. The handheld automatic reader will undergo further modification and improvements to provide for ...

We propose to develop a universal strategy to encapsulate protein-based therapeutics using our patented non-toxic, non-immunogenic, water soluble, nanometer size capsules. These nanocapsules have a functionalized surface rendering them "unseen" by the normal immunogenic scavenging response of the body. In addition, the nanoencapsulated proteins not only exhibit superior shelf stability, but are ...

We propose to develop a multiplexed immunoassay for the detection of 2 - 4 medically relevant biomarkers of traumatic brain injury for use by front-line medical personnel and their civilian equivalents. The assay will provide results in less than 30 minutes, and provide information as to the actual level (concentration) of the biomarkers in the patient. The sample size for operating the assay is ...

The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism threat. There are currently no therapeutic agents available to treat filovirus infections and the de ...

The purpose of this proposed research is to develop a rapid field test system for detection of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) infection in humans and rodents using a lateral-flow immunoassay. This assay will have a broad technical impact in that it can be used in animal laboratories interested in ascertaining if their mice or rats have hantavir ...

The technology resulting from this effort will provide a comprehensive thermomechanical/ impact wear model. This integrated model will consider the developed thermal energy due to sliding friction and impact loading of the wear surface. In addition to the development of the theoretical model, a unique bench wear fixture will be designed, fabricated, and validated. This fixture will provide varia ...

In Phase I, EM Photonics demonstrated the viability of using a reconfigurable hardware approach to accelerating the simulation of electronic circuits based on their electromagnetic properties. In Phase II, this technology will be used to create a solver capable of analyzing mixed signal circuits 64 times faster than is currently available from equivalent software. The resulting device will shrin ...

The overall objective of this Phase II project is to optimize the fabrication procedure associated with the chemical lithography proposed in Phase I to fabricate nanophotonic structures and devices at a fraction of the cost of existing technologies. We plan to use our optimized chemical lithography procedure to fabricate an ultra-high resolution patterns and devices including nano-probe for near f ...