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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery

    SBC: IsoPlexis            Topic: 105

    In this Phase I application IsoPlexis proposes to deliver a novel method for targeted profiling of both the transcriptome and secretome from an array ofsingle central and peripheral immune cellsSpecificallywe will deliver a single cellmRNA and secreted protein capture assay with proven sensitivity for detecting the most important predictive biomarkers for neurodegenerative diseasesThere is growing ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance

    SBC: IsoPlexis            Topic: 102

    Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Robust Predictor of Colon Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 102

    Summary At leastpeople in the United States are at high risk for Lynch syndromebased on inheritance of a genetic mutation in the mismatch repairMMRor double strand breakDSBrepair pathwayMore than half of them are unaware of their riskbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in this pathwaybut in a large number of cases no mutati ...

    STTR Phase I 2018 Department of Health and Human Services
  5. IMPROVEMENT TO OZONATING WATER FOR POST-HARVEST WASHING THROUGH NANOBUBBLES

    SBC: En Solucion Inc            Topic: FDA

    AbstractAs consumer demand for fresh produce continues to growso do concerns by the Food and Drug AdministrationFDAabout foodborne illnesses and foodborne disease outbreaksPostharvest wash is a critical control point in fresh produce processing for reducing or eliminating pathogens and other field acquired contaminants that can result in such outbreaksCurrent methods of post harvest washing typica ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Development of an a MC1R selective companion diagnostic imaging probe

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    The melanocortinreceptorMC Ris over expressed on uveal and cutaneous melanoma cellsbut notin healthy normal tissuesWe have developed a proprietary ligandMTIthat binds to MC R inmelanoma cells with high affinity and specificityThrough our SBIR Phase I contractwedemonstrated that MC R targetedAc DOTA MTIlacks of overt toxicity at single doses thatproduce significant efficacy against uveal and cutane ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Authentication quantitation and detection of adulteration in botanical dietary supplements using an automated chemometric platform

    SBC: MIDI, INC.            Topic: FDA

    Abstract The objective of this SBIR Phase I proposal is to test the feasibility for development of an automated platform that can perform the followingIdentify botanical components of dietary supplements throughout the supply chain by use of chemicalanalysis and integrated pattern recognition softwareDetect the presence of adulteration by use of HPLCand UHPLCanalysis of bioactive compounds andby u ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Novel, Nanostructured, Metal-organic Frameworks-Based Product Loss Prevention Technology in the Oil and Natural Gas Sector

    SBC: Framergy, Inc.            Topic: 17NCER2C

    To reach the end user, oil and gas production at the wellhead must be transmitted through the country and distributed to a wide range of customers. This logistical system requires natural gas gathering lines, processing facilities, product storage tanks and lots of other equipment. What results is air pollution caused by industry losses during these operations and the use of continuous or intermit ...

    SBIR Phase I 2018 Environmental Protection Agency
  9. Additive Manufacturing for RF Materials and Antennas

    SBC: DeLUX Engineering, LLC            Topic: A18020

    To reduce size, weight, power and cost (SWaP-c), military platforms have been evolving towards more integrated platforms that utilize all available space. For radiating systems, this will require exploring innovative design methods, materials and manufacturing approaches to realize cost-effective, customizable and conformal antennas. An attractive solution to this challenge is offered by additive ...

    SBIR Phase I 2018 Department of DefenseArmy
  10. Low-cost Imager for Heavily Degraded Visual Environments

    SBC: Phase Sensitive Innovations, Inc.            Topic: A18040

    This project aims to develop a low-cost millimeter-wave (mmW) imaging system for ground vehicles, to operate in combination with a long-wave infrared (LWIR) camera. Such a system will mitigate the challenges of driving in degraded visual environments (DVE) including night time, fog, dust, or smoke by providing real-time image of the vehicle surrounding independent from the presence of naturally oc ...

    SBIR Phase I 2018 Department of DefenseArmy

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