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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. PLGA encapsulated polyphenols to ameliorate IBD.

    SBC: THERAPYX, INC.            Topic: R

    Abstract Green tea has received increased attention recentlydue to several epidemiological and clinical studies showing a positive relationship between consumption and disease preventionBenefits include reduced risk of cardiovascular diseasese gmyocardial infarctionhypertensionatherosclerosisneurodegenerative diseasese gParkinson s and Alzheimer s diseaseand certain cancerse ggastricbreast and cer ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Left atrial appendage closure device with catheter-based delivery for patients with non-valvular atrial fibrillation

    SBC: Cor Habere Corp.            Topic: R

    In the USthere aremillion patients with nonvalvular atrial fibrillationNVAFwhich is expected to increase tomillion byThe treatment of NVAF is estimated to cost $billionincluding $billionfor hospitalizations aloneThe most significant morbidity and mortality associated with NVAF is embolic strokewithof thrombus originating from the left atrial appendageLAAAnticoagulation is the preferred treatment f ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of a sutureless LVAD outflow graft anastomotic quick-connect system

    SBC: Myocardial Assist Systems & Technology LLC            Topic: NHLBI

    Heart failureHFis the leading cause of death in the United Statesaffecting nearly six million people at a cost over $billionClinically approved mechanical circulatory supportMCStherapysuch as left ventricular assist devicesLVADscontinue to improve as a viable treatment option for patients with advanced heart failure as evidenced by overimplants over the past five yearsHoweverMCS device therapy can ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Robust Predictor of Colon Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 102

    Summary At leastpeople in the United States are at high risk for Lynch syndromebased on inheritance of a genetic mutation in the mismatch repairMMRor double strand breakDSBrepair pathwayMore than half of them are unaware of their riskbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in this pathwaybut in a large number of cases no mutati ...

    STTR Phase I 2018 Department of Health and Human Services
  5. DIAGNOSTIC TEST FOR METASTATIC KIDNEY CANCER

    SBC: LaGrange Scientific, LLC            Topic: 102

    ABSTRACTThe goal of this Phase I SBIR is to address the absence of measureable and targeted metabolite biomarkers in clear cell renal cell carcinomaccRCCtissues that can predict disease metastasisAn estimatedAmericans were diagnosed with kidney cancer inand approximatelydied as a result of ccRCCprimarily due to metastasis of the cancerUltimatelywe seek to identify those patients with more aggressi ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Development of an a MC1R selective companion diagnostic imaging probe

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    The melanocortinreceptorMC Ris over expressed on uveal and cutaneous melanoma cellsbut notin healthy normal tissuesWe have developed a proprietary ligandMTIthat binds to MC R inmelanoma cells with high affinity and specificityThrough our SBIR Phase I contractwedemonstrated that MC R targetedAc DOTA MTIlacks of overt toxicity at single doses thatproduce significant efficacy against uveal and cutane ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leads

    SBC: NAPROGENIX, INC.            Topic: NINDS

    Abstract Alpha synucleinASYNis believed to play an important role in the pathology of several neurodegenerative conditionsincluding some forms of Parkinsonandapos s diseaseDementia with Lewy Bodiesand Multiple Systems AtrophyThe most recent hypothesis is that the ASYN proteinsparticularly genetic variants such as AT that are prone to misfoldingare cleaved by the lysosomal enzymeasparagine endopept ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Noninvasive Seizure Screening in Preclinical Models of Epilepsy

    SBC: SIGNAL SOLUTIONS, LLC            Topic: 100

    Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Exploiting activation-induced cell death as a means of inducing tolerance to kidney allografts

    SBC: FasCure Therapeutics LLC            Topic: NIAID

    PROJECT SUMMARY Kidney transplantation is the preferred treatment for patients with end stage renal diseaseHoweverstandard immunosuppression to control rejection is the major limitationAlthough standard immunosuppression has gradually been improved for better efficacy and safetyit still carries a great risk for adverse effects ranging from malignancies and infections to cardiovascular complication ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Development of a Percutaneous Pulmonary Artery Drainage Device to Unload LV During VA ECMO Support for Severe Cardiogenic Shock

    SBC: W-Z Biotech LLC            Topic: NHLBI

    Cardiogenic shockCSis a serious clinical condition of reduced cardiac outputCOwith end organ hypoperfusionIn severe CSend organ hypoperfusion leads to multi organ failureand elevated left ventricleLVpreload increases LV wall stressexacerbating myocardial injuryVenoarterial extracorporeal membrane oxygenationVA ECMOhas been increasingly used to support severe CS patients due to its high efficiencyc ...

    SBIR Phase I 2018 Department of Health and Human Services
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