Award Data

OPTOELECTRONIC SOURCES, INTEGRATED AS MONOLITHIC ELEMENTS ON SILICON VLSI CHIPS, OFFER IMPORTANT ADVANTAGES IN THE TRANSMISSION OF INFORMATION WITHIN THE CHIP OR BETWEEN CHIPS IN ADVANCED COMPUTER SYSTEMS. THE SPEED OF OPTICAL-INTEGRATED VLSI DEVICES IS EXPECTED TO BE CONSIDERABLY HIGHER THAN EQUIVALENT VLSI WITH METALLIC INTERCONNECTS, DUE TO ABSENCE OF THE RC DELAY INHERENT IN THE METALLIC CONDU ...

OBJECTIVES OF THIS PROJECT ARE TO DEVELOP AN INEXPENSIVE DISPOSABLE UNDERGARMENT DEVICE FOR EARLY AUTOMATIC DETECTION OF URINATION AND TO DESIGN A QUANTITATIVE DEVICE TO BE USED IN CLINICAL RESEARCH AND OTHER APPLICATIONS. THE ELECTRONIC OUTPUT OF THE DETECTOR SYSTEM WILL TRIGGER A SIGNAL TO BE OBSERVED BY THE PERSON WEARING THE GARMENT AND/OR BY OTHERS (NURSE, ETC.). THE DEVICES WILL BE USEFULL A ...

To reach the end user, oil and gas production at the wellhead must be transmitted through the country and distributed to a wide range of customers. This logistical system requires natural gas gathering lines, processing facilities, product storage tanks and lots of other equipment. What results is air pollution caused by industry losses during these operations and the use of continuous or intermit ...

SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

PROJECT SUMMARY Chronic rhinosinusitis (CRS) is one of the most prevalent inflammatory diseases in the U.S., affecting up to 16% of the population and substantially diminishing the quality of life and productivity of patients. In four years, the annual U.S. health care expenditure to treat patients with CRS dramatically increased from $9B to $64B (5% of the health care budget), with a correspondin ...

Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

In this Phase I application IsoPlexis proposes to deliver a novel method for targeted profiling of both the transcriptome and secretome from an array ofsingle central and peripheral immune cellsSpecificallywe will deliver a single cellmRNA and secreted protein capture assay with proven sensitivity for detecting the most important predictive biomarkers for neurodegenerative diseasesThere is growing ...

Although signal transduction inhibitors occasionally offer clinical benefit for cancer patientssignal flux emanating from oncogenes is often distributed through multiple pathwayspotentially underlying the resistance which causes failure of most such inhibitorsMeasuring signal flux through multiple pathwaysin response to signal transduction inhibitorsmay help uncover network interactions that contr ...

Summary At leastpeople in the United States are at high risk for Lynch syndromebased on inheritance of a genetic mutation in the mismatch repairMMRor double strand breakDSBrepair pathwayMore than half of them are unaware of their riskbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in this pathwaybut in a large number of cases no mutati ...