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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Assistive Device to Improve Object Recognition and Reading

    SBC: Aeon Imaging, LLC            Topic: na

    The goal of this project is to create an affordable system for optimizing the use of assistive devices (tablets) to improve reading and object recognition performance for individuals with visual impairments. The objectives are: (1) to select a suitable assistive device that can be paired with Aeon’s existing Digital Light Ophthalmoscope (DLO-LV) vision research retinal camera which maps the posi ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Confocal and Autofluorescence Imaging of Macular Degeneration using a Low Cost Digital Imager

    SBC: Aeon Imaging, LLC            Topic: W

    Project SummaryAbstract The overall goal of the proposed SBIR Phase II research is to build and evaluate a low costmulti mode retinal camera used to detect and manage causes of macular impairmentAge related macular degenerationAMDremains the most common cause of permanent vision loss in the US and many industrialized countriesTreatments with portable lasers and injectable drugs can save sightbut e ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY Chronic rhinosinusitisCRSis one of the most prevalent inflammatory diseases in the U Saffecting up toof the population and substantially diminishing the quality of life and productivity of patientsIn four yearsthe annual U Shealth care expenditure to treat patients with CRS dramatically increased from $ B to $Bof the health care budgetwith a corresponding rise in surgical treatment ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIEHS

    Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA InitiativeThe United States Environmental Protection AgencyEPAis establishing new safeguards for hazardous secondary materials with objectives to promote the economicenvironmentaland public health benefits of recycling wasteswith an emphasis on several industrial sectorsincluding the pharmaceutical industryOn averagepharmaceutical m ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Polymeric nanoparticles for inductive browning of white adipose tissue

    SBC: ADIPO THERAPEUTICS, LLC            Topic: 200

    Global epidemics of obesity and its associated comorbidities pose formidable challenges to human healthCurrent few medications available for obesity treatment only produce modest effects and are usually accompanied with unpleasantpotentially harmful side effectsThere is accumulating evidence that significant metabolic differences that distinguish beige brown adipocytes from white adipocytes can po ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction

    SBC: ANAGIN            Topic: 103

    Abstract This applicationDevelopment of novel small molecule analgesics modulating the nNOS NOS AP proteinprotein interactionaddresses the critical need for more effective medications to treat chronic neuropathic pain affectingmillion people in the United StatesCurrent pain medications such as NSAIDSsteroidsopiates and gabapentin analogs have documented and often severe side effectsare poorly effe ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Development and feasibility of prevention-minded oral health mobile App based on dietary selections and oral hygiene events.

    SBC: Indiana Nanotech, LLC            Topic: NIDCR

    The number of decayed and filled tooth surfaces in primary dentition is on the rise in US children between the ages ofandyears oldin factof adolescentsbetweenandyears oldandout ofdentate seniorsagebear evidence of dental cariesReinforced with areport statingof those between the ages ofandhave dental cariesvirtually all walks of life are thus affectedand this doesn t even include those unreportedor ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Fluoroscopic drill attachment for orthopedic trauma surgery

    SBC: Eclipse Orthopaedics, LLC            Topic: NIAMS

    Abstract Aboutleg and hip fractures each year are treated by implanting a stiff metal rod or intramedullaryIMnailthrough the center of the bone and fixing the ends of the nail to the bone with screwsBut placing the locking screws to fix the rod to the bone is difficultTo anchor the nail securelythe surgeon must accurately drill pilot holes through both the bone and locking holes in the nailwhile t ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Software and services to advance does-response modeling in chemical risk assessment

    SBC: KS and Associates LLC            Topic: NCATS

    PROJECT SUMMARY Chemical risk assessment has been widely applied in chemical industry as a necessary step to get new commercial chemicals registeredand in governmental agencies as a critical procedure to evaluate the toxicity of chemicals in order to properly regulate them to protect human health and the environmentThe Lautenberg Chemical Safety Act further strengthens the importance of chemical r ...

    STTR Phase I 2018 Department of Health and Human Services

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