Award Data

DESCRIPTIONprovided by applicantSignificanceThe USPHSTFSAMHSACDCand NIAAA have affirmed the importance of screening in medical settings for alcohol consumption that exceeds the NIAAA low risk limitsbrief educational and motivational counseling for those who screen positive or have other evidence of an Alcohol Use Disorderandwhen appropriatereferral to treatmentSBIRTHowevertranslation to clinical p ...

DESCRIPTION provided by applicant By January oncology care providers will be expected to craft Survivorship Care Plans SCPs for all individuals ending active treatment for cancer however there is a lack of systematic study of the impact survivorship planning has on patients providers or healthcare systems The Polaris Oncology Survivorship Transition POST program is a web based sy ...

DESCRIPTION provided by applicant Multiple myeloma MM is the second most common hematological malignancy in the United States and remains an incurable disease since nearly all MM patients will eventually relapse and develop resistance to currently available drugs Sphingolipid metabolism is being increasingly recognized as a key pathway in tumor biology In particular sphingosine kinases S ...

DESCRIPTIONprovided by applicantKeystone Nanoin partnership with the University of Maryland Greenebaum Cancer CenterUMD GCCproposes a multi site clinical evaluation of the Ceramide NanoLiposomeCNLas a novel anti cancer therapeuticThe overall objective of this project is to advance the CNL through a Phase I clinical trialThe results of this trial will support subsequent trials for the intended init ...

DESCRIPTION provided by applicant Over million people in the United States are infected with HIV AIDS African American adolescents AAAs represented of HIV AIDS cases among to year olds In addition almost of adolescents with HIV do not know they are infected Testing for HIV may result in earlier diagnosis and reduced likelihood of transmission In this study our tea ...

DESCRIPTION provided by applicant Barrettandapos s esophagus is a pre neoplastic disease that predisposes patients to development of esophageal adenocarcinoma EAC Approximately million people in the US have Barrettandapos s esophagus and they are frequently screened by endoscopy with pathological analyses of esophageal biopsies The goal of the screening is to detect premalignant changes e ...

DESCRIPTIONprovided by applicantHepatocellular carcinomaHCCis usually undetected until its later stageswhere theyear survival rate for patients is less thanHoweverthe survival rate can be as high asif the cancer is detected earlyUnfortunatelyearly detection of HCC is not possible with any screening tests that are currently availablesuch as ultrasound or imaging technologiesAlpha FetoproteinAFPwhic ...

DESCRIPTION provided by applicant The smallpox virus variola has been responsible for the deaths of hundreds of millions of people worldwide Although smallpox was eradicated from the globe in following a valiant immunization campaign existing viral stocks may fall into the hands of those seeking to employ variola as a biological weapon This calls for the development of safe antiviral ...

DESCRIPTION provided by applicant Recent advances in the size and performance of micro electromechanical systems MEMS based inertial instruments enable the development of a novel balance prosthesis to provide feedback via a substitute sensory channel regarding head orientation to patients with chronic balance dysfunction There is a need for balance prostheses to assist patients with chronic ...

DESCRIPTION provided by applicant One in African American women will be diagnosed with HIV in her lifetime compared to in White women Beyond abstinence the most effective way to prevent HIV is the male condom Because condoms are male controlled women are often unable to negotiate their use This is especially true for African American women who are often socialized to be sexually ...