Award Data

DESCRIPTIONprovided by applicantSignificanceThe USPHSTFSAMHSACDCand NIAAA have affirmed the importance of screening in medical settings for alcohol consumption that exceeds the NIAAA low risk limitsbrief educational and motivational counseling for those who screen positive or have other evidence of an Alcohol Use Disorderandwhen appropriatereferral to treatmentSBIRTHowevertranslation to clinical p ...

DESCRIPTION provided by applicant By January oncology care providers will be expected to craft Survivorship Care Plans SCPs for all individuals ending active treatment for cancer however there is a lack of systematic study of the impact survivorship planning has on patients providers or healthcare systems The Polaris Oncology Survivorship Transition POST program is a web based sy ...

DESCRIPTION provided by applicant Multiple myeloma MM is the second most common hematological malignancy in the United States and remains an incurable disease since nearly all MM patients will eventually relapse and develop resistance to currently available drugs Sphingolipid metabolism is being increasingly recognized as a key pathway in tumor biology In particular sphingosine kinases S ...

DESCRIPTIONprovided by applicantKeystone Nanoin partnership with the University of Maryland Greenebaum Cancer CenterUMD GCCproposes a multi site clinical evaluation of the Ceramide NanoLiposomeCNLas a novel anti cancer therapeuticThe overall objective of this project is to advance the CNL through a Phase I clinical trialThe results of this trial will support subsequent trials for the intended init ...

DESCRIPTION provided by applicant Aquilus Pharmaceuticals Inc proposes to preclinically develop AQU for the treatment of orofacial and general neuropathic pain via a newly discovered mechanism involving matrix metalloproteinases andamp MMP MMP AQU is a non hydroxamic acid containing MMP inhibitor that is selective for both MMP and MMP and has been shown to block mech ...

DESCRIPTION provided by applicant Barrettandapos s esophagus is a pre neoplastic disease that predisposes patients to development of esophageal adenocarcinoma EAC Approximately million people in the US have Barrettandapos s esophagus and they are frequently screened by endoscopy with pathological analyses of esophageal biopsies The goal of the screening is to detect premalignant changes e ...

DESCRIPTION provided by applicant The goal of the project is to develop a therapeutic capable of sterilizing recalcitrant chronic infections such as deep seated abscess osteomyelitis endocarditis and biofilms of indwelling devices Many of these infections are essentially untreatable and lead to substantial morbidity and mortality In many cases recalcitrance of an infection is not caused b ...

DESCRIPTION provided by applicant The overall objective of this Fast Track SBIR application is to create and deploy an innovative system that will help more elders to continue living at home while being safely cared for by Personal Care Service PCS agencies Based on the research teamandapos s prior experience developing fall sensors and other technologies to allow elders to andquot age in pl ...

DESCRIPTIONprovided by applicantHepatocellular carcinomaHCCis usually undetected until its later stageswhere theyear survival rate for patients is less thanHoweverthe survival rate can be as high asif the cancer is detected earlyUnfortunatelyearly detection of HCC is not possible with any screening tests that are currently availablesuch as ultrasound or imaging technologiesAlpha FetoproteinAFPwhic ...

DESCRIPTION provided by applicant Multi drug resistance MDR in Gram negative pathogens including the Enterobacteriaceae and Pseudomonas aeruginosa poses a significant threat to our ability to effectively treat infections caused by these organisms A major component in the development of the MDR phenotype in Gram negative bacteria is overexpression of RND type efflux pumps which actively pu ...