Award Data

DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Neonatal and childhood seizures can increase an individual's susceptibility for developing epilepsy later in life. Obtaining long-term continuous recordings of electrical events, such as the electroencephalogram (EEG), from animal models of neurological disease is a critical comp ...

Oscilla Power, Inc. (OPI) is developing a utility-scale wave energy harvester that is enabled by low cost and readily-available magnetostrictive alloys. T his device, which utilizes no moving parts, has the potential to deliver predictable quantities of electric power to coastal utilities, industrial users, and remote facilities at costs competitive with coal or gas. The Phase I project demonstra ...

This Phase II research expands Phase I research on Saccharina latissima and is to design and develop “seed” nursery methodologies for the development of commercial-scale production of juvenile kelp plants including Alaria esculenta and Laminaria digitata. The project objectives include: 1. Isolate and maintain cultures of New England species of Alaria esculenta and laminaria digitata to be use ...

Marine aquaculture production now exceeds 20 million metric tons annually (FAO 2010) but viral diseases are still a major threat to the expansion of sustainable mariculture systems (National Marine Fisheries Service 2007). Pathogenic viruses continue to devastate many fish and shellfish operations every year (ICES Mariculture Committee 2004, Lightner 2011). To date, vaccines against aquatic anim ...

DESCRIPTION (Applicant's Abstract): The overall goal of this research proposal is to determine the effectiveness of recombinant human lactoferrin (rhLF) for treating gastrointestinal (GI) disorders. This Phase II proposal will focus on the ability of rhLF to treat the 01 side effects of non-steroidal anti-inflammatory drugs (NSAIDs), a class of drugs widely-us ...

DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring every year. This means that in the United States, more than 500 patients die from severe sepsis every day, with 28% to 50% of the patients succum ...

DESCRIPTION (provided by applicant): During Phase I of our proposed research, we will develop and validate procedures for recovering, labeling, and analyzing miRNAs from fixed tissue samples. The procedures will be based on the miRNA microarray and fix ed tissue RNA isolation systems that we developed in other SBIR-funded programs. The development of our miRNA isolation and labeling procedures ...

DESCRIPTION (Provided by Applicant): The implications of developing materials with enhanced fracture toughness, damage resistance, reliability and ultra low wear is of significant interest to the orthopedic community, since it directly addresses a vital clinical concern- eliminating wear debris mediated THA implant failures. In Phase I we made a significant ...

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DESCRIPTION (provided by applicant): Dramatic increases in computer speed and the development of on-screen keyboards that send text to commercial software programs provided the foundation for this innovative approach to assisted typing. In Phase I, this new approach "Smart Key Technology (TM)" (SKT) was investigated, further developed, and tested. Using "letter p ...