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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Sphingosine Kinase Inhibitors as Anti-Arthritis Agents

    SBC: Apogee Biotechnology Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine 1-phosphate produced by sphingosine kinase (SK) mediates the effects of tumor necrosis factor-1 and interleukin-12, pro-inflammatory cytokines ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Sprayable Surgical Adhesive for Seroma Prevention

    SBC: COHERA MEDICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this project is to create a sprayable surgical adhesive which would satisfy the surgical need for a strong, easy-to-use adhesive to adhere planar flaps of tissue. This novel adhesive will reduce fl uid accumulation after surgery by eliminating dead space in the wound and maintaining tissues in position for natural healing to occur. Seroma ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  3. CAD-CAM Technology for Diabetic Footwear

    SBC: DIAPEDIA, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diabetes remains the leading cause of non-traumatic lower extremity amputations. Most amputations are preceded by a foot ulcer, so that successfully treating, or better still preventing, foot ulcers should reduce the n umber of diabetes related amputations. The majority of foot ulcers in diabetic patients are the result of loss of protective sensation (LOPS) s ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  4. Biocompatible Coating for Pediatric Blood Oxygenators- Phase II

    SBC: ENSION Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Many oxygenators clinically available for pediatric (and adult) extracorporeal membrane oxygenation (ECMO) utilize heparin coatings such as Carmeda BioActive Surface on device surfaces, including the microporous hollow fibers, to improve biocompatibility. Despite application of these coatings, significant inflammatory and coagulation-related complications, as ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Web-based stroke education for patients and families

    SBC: Fox Learning Systems, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Ischemic stroke is a major source of illness burden in the US. Stroke survivors are at high risk for recurrence and therefore they are an important group for secondary prevention. However, gaps in knowledge among stroke survivors, including inadequate knowledge of the early warning signs of stroke, inadequate understanding of the purpose and goals of rehabilit ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  6. Not Available

    SBC: Fox Learning Systems, Inc.            Topic: N/A

    SUMMARYOF OBJECTIVES: 1. Develop a comprehensive curriculum of geriatric mental health education using Web-based interactive video documentary presentations. 2. Modify the presentations of each topic so that can be used to meet the educational needs of medical students, residents, as well as nursing, social work, pharmacy and psychology and will meet the requirements for CME and CE credits to prof ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Cell-free Detection of GPCR Signaling in a Nanoscale System

    SBC: INTEGRAL MOLECULAR, INC            Topic: N/A

    DESCRIPTION (provided by applicant): G protein-coupled receptors (GPCRs) are one of the most important families of pharmaceutical targets. However, some of the most desirable types of GPCR drugs have also been some of the most difficult to discover. GPCRs are integral membrane proteins that are traditionally studied in live cells or cell membrane preparations, sources that limit the ability to pu ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  8. SUMO Fusions to Enhance Expression of Membrane Proteins

    SBC: LIFESENSORS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Rather modest success has yet been achieved in expressing and purifying membrane proteins as a prerequisite to obtain high resolution structures. Only 124 unique structures for membrane proteins have been resolved out o f gt 30,000 soluble proteins. This bottleneck can be divided into at least three major parts: i) the difficulty to express quantitatively and ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Intravesical Liposome Treatment for Interstitial Cystitis

    SBC: LIPELLA PHARMACEUTICALS INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Interstitial cystitis (IC) is a chronic, severely debilitating disease of the urinary bladder. It can be described as a chronic inflammatory condition of the bladder wall, characterized by urinary frequency and urgency, and severe suprapubic and/or pelvic pain. Presently, there is limited medical therapy for IC and new and effective treatment is a major unmet ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a cost-effective pmMRI for in vivo structural examination of bone

    SBC: MICROMRI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): MicroMRI, Inc. Development of a cost-effective pfMRI for in vivo structural examination of bone Abstract Osteoporosis is a systemic bone disease characterized by low bone mass and abnormal bone quality. The current "gold standard", dual-energy x-ray absorptiometry (DXA), cannot assess bone quality and fails to detect > 50% of persons at greatest risk of fractur ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
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