Award Data

Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

The SBIR Phase II proposal outlines the approach of Night Crew Labs (NCL) in designing, and developing, and testing a system prototype to perform Global Navigation Satellite System radio occultations (GNSS-ROs) from a high-altitude balloon platform. NCL will continue building from the positive results achieved in Phase I that successfully demonstrated the feasibility of performing balloon-borne GN ...

Phase-1 demonstrated the powerful and unusual remote sensing opportunities available by adding acoustic signal detection to pop-up satellite tags (PSAT). The time and location of spawning define the starting point in the life history of fish. Yet this event, which is of critical importance to fishery researchers and managers seeking to gain an understanding of distinct reproductive populations and ...

Subsurface mooring beacons are used to provide notifications and assist in locating moored assets that have surfaced and are free drifting. Their nominal design is driven by the requirements for offshore use where they need to survive extreme depths and remote deployment, most often using satellite constellations for communication and geo-location. Existing beacons serve their purpose well, but th ...

The presence of fog reduces visibility, contributing to unsafe conditions for many maritime tasks. The current system uses active backscatter and has high power requirements, high maintenance and replacement costs. Areté Associates’ innovative FogViewer system comprises a passive multi-spectral, multi-polarization sensor suite that leverages available degrees of freedom to best characterize the ...

The goal of this project is to develop a diagnostic that can support the enrollment of seronegative individuals in clinical trials of candidate cytomegalovirusCMVvaccinesCongenital CMV infection is one of the leading causes of non genetic birth defects worldwideIf a successful vaccine can be brought to marketit will have a significant impact on the number of babies born with hearing and vision los ...

The proposed work aims to develop a pre commercial prototype of an exosome isolation device to be used in clinical diagnostic laboratoriesWe will advance the device to facilitate exosome isolation for downstream liquid biopsy tests requiring analysis of proteinDNAor microRNAwhich rely upon acquisition of intact and pure exosomesThe device strategy will be designed to isolate total exosomes and the ...

Chemotherapy may control but rarely cure metastatic cancersRemarkablymodern immunotherapiesincluding cell based therapieshave cured metastatic melanomas and other types of cancersA major challenge for all cell therapies in general is the need to develop cost effective and efficient manufacturing and delivery capabilitiesWe have recently established an innovative cell isolation technology by applyi ...

The goal of the research is to develop a highly accurateautomatedand low cost ctDNA test to monitor efficacy of treatment of metastatic breast cancer patients by identifying the emergence of certain DNA mutations in plasma samplesThere is growing evidence that the presence of certain DNA mutations in the blood stream correlates with breast cancer becoming resistance to hormone treatmentNVIGEN will ...