Award Data

Adenosine produces coronary vasodilation through activation of A-2a adenosine receptors. However adalso acts at A1 adenosine receptors to slow atrioventricular conduction and when injected into man ican be blocked with A1 receptor antagonists. DTI has synthesized a number of adenosine analogs that2a subtype of adenosine receptor and have identified WRC-0470 as a potent selective short acting corou ...

The Internet is an evolving web of interconnected computer networks offering information resourcesinfinite proportions. Unfortunately, the computer lay person experiences formidable barriers to accAwkward commands and clumsy menus are intimidating - attempting to navigate Internet can be likenedforeign country without a map and with no grasp of the language. Compounding this problem is the fainf ...

A COMPUTERIZED DATABASE IS TO BE DEVELOPED TO MANAGE AN INTERVIEW SERVICE FOR CLIENTS OF AGENCIES OFFERING SERVICES TO THE ELDERLY. CASEWORKERS, PROMPTED BY THE DATABASE, WILL PERIODICALLY PHONE CLIENTS IN ORDER TO CHECK THEIR ONGOING HEALTH AND SOCIAL STATUS, TO RELAY TIMELY HEALTH INFORMATION. THE RESULTING PRODUCT WILL BE A COMPUTER PROGRAM AND A PROCEDURE FOR ITS USE WHICH SHOULD ALLOW MORE EF ...

The long-term objectives of this SBIR project are to fully adapt the EMPOWER expert system softwaredeveloping HIV prevention programs at the community level and to develop an evaluation component forwhich would examine the process, outcome, and impact of resulting programs. Phase I will involve tesadapting such a produce to meet the needs of community- level planners in HIV prevention program plae ...

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In the 1990's, there are great costs to society, families, and youth from morbidity and mortality rfrom adolescent conflicts. Behavioral research has identified a number of promising approaches to busocial problem-solving skills. However, additional research is needed to create innovative preventiopromote their pro-social conflict resolution skills and to widely disseminate them in ways that woulc ...

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With the combined effects of a rapidly growing elderly population and advances in medicaltechnology, the need for decision making about appropriate medical treatments for elderly individualshas increased. Education about advance directives, legal documents which identify patients' decisionsregarding medical treatments, has not been systematically directed toward elderly adults residing in thecommu ...

This research will develop and demonstrate a new gripping tool for microsurgery that exhibitssuperior performance and extended life over current state-of-the-art stainless steel microsurgical forceps.Current stainless steel forceps rely on the alignment of gripping teeth to achieve high gripping power andsuffer from short service lives as a result of frictional and corrosive wear associated with m ...

DESCRIPTION (provided by applicant): In our previous work we identified a series of potent cell-wall inhibiting dipiperidines that are structurally unrelated to any existing antitubercular drugs. After extensive analysis of the lead molecules for anim- icrobial activity and drug properties compound SQ609 was selected as the most promising candidate: it has excellent in vivo activity, favorable pha ...