Award Data

DESCRIPTION provided by applicant The Development and Assessment of Video Based Directly Observed Treatment for Tuberculosis TB is a project to develop a patient centered cost saving alternative strategy to ensure TB treatment completion TB disproportionately affects vulnerable populations and there are barriers to TB care `Directly observed therapyandapos DOT is the recommended standa ...

DESCRIPTION provided by applicant Impaired wound healing is an unfortunate consequence of diabetes It is also seen in the elderly as well as individuals taking steroid medication There is an urgent need for a therapy that will be safe effective and easy to apply to improve impaired wound healing The situation is most urgent for individuals with diabetes whose foot ulcers are the most fre ...

DESCRIPTION provided by applicant In the proposed study a novel approach which has already generated multiple commercial sales for SilcsBio LLC Site Identification by Ligand Competitive Saturation SILCS will be further developed to address customer requests and concerns around SILCS utility Successful commercial application of computational methods for ligand design require a platform th ...

DESCRIPTION provided by applicant The United States have the highest annual incidence rates of breast cancer in the word It is the second most common cancer after skin cancer and the second most common cause of cancer death after lung cancer It is estimated that in there will be an estimated new cancer cases diagnosed and cancer deaths in the US Worldwide more ...

DESCRIPTION provided by applicant In the treatment of acute artery disease percutaneous interventions using drug eluting stents are the preferred method of treatment Although effective for simple conditions e g short lesions single vessels when treating tortuous or bifurcating vessels drug eluting stents can provide incomplete drug coverage resulting in neointimal hyperplasia or acute ...

DESCRIPTION provided by applicant The specific aim of this proposal is to test the feasibility of developing a tool for the simultaneous and continuous measurement of pharmaceutical drug concentrations and electrophysiology recording in the brain for preclinical testing of central nervous system CNS drug candidates The benefits of the proposed tool are three fold improved method of perfo ...

DESCRIPTION provided by applicant Vaccines are a rational and cost effective means for protecting against infectious diseases in travelers military personnel and in endemic developing country populations Our goal in this proposal is to address several significant vaccine needs the need for an easy to administer needle free and safe oral vaccine vector platform for stable expression an ...

DESCRIPTION provided by applicant This proposal will demonstrate proof of concept for a whole parasite WP vaccine directed against Plasmodium falciparum Pf sexual and mosquito stages SMS that will be used alone or in combination with PfSPZ Vaccine for interrupting malaria transmission VIMT from the human host to the mosquito vector Such a PfSMS WP VIMT will be an ideal complement to t ...

DESCRIPTION provided by applicant Childhood and adolescent obesity is a growing epidemic in the United States especially among minorities Research has repeatedly shown that African American youth are disproportionately affected by the obesity epidemic especially African American girls By almost percent of black girls were obese the highest prevalence of any age group by gender ...

DESCRIPTION provided by applicant Objectives and optics for are rapidly evolving to allow wider and wider FOVs for two photon laser scanning microscopes PLSM This development introduces a new challenge point by point raster scanning over the entirety of the FOV requires the experimenter to sacrifice either single cell sensitivity because of faster scanning rates required to cover the lar ...