Award Data

ABSTRACT Stroke is one of the leading causes of death and disability in the United States and other developed countriesAboutpeople in the United States have a stroke each yearThe incidence of stroke is expected to increasedue to diabetesan aging population and a rise in obesitywhich is a major public health concern and great economic burden to societyEarly identification of people at risk of strok ...

Project Summary The goal of this project is to significantly enhance our understanding and treatment of inadequate balance responses in the elderly and in patients with neurological impairments following external perturbations such as a slip or trip Our laboratory studies have shown that balance responses can be improved with practice in the elderly and in patients with Parkinsonandapos s disease ...

Project SummaryAging increases the risk of GI disorders such as CRCinflammatory bowel diseaseand appendicitisNIH statistic shows that an estimatedtomillion Americans are affected by gastrointestinal diseases annually and nearlyof older adults have one or more age related digestive symptom each yearUnfortunatelythe increasing global geriatric population base is expected to further worsen this situa ...

ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

The work described in this proposal addresses the clinical deficiency of the currently available oral treatments for hypothyroidism Approximately of persons suffering from hypothyroidism report insufficient symptomatic improvement from levothyroxine T Synthroid alone This is thought to be related to a genetic variation in the enzyme that converts T to T the active form of thyroid hor ...

This project will explore the translational potential of a new PET molecular imaging probe Ga PC for detecting very small cancers and distinguishing between localized and metastasized cancers in bone and soft tissue mouse models Ga PC will be evaluated for metastatic prostate PC and pancreatic PaCa cancers Early detection of the most lethal PaCa with andlt survival for y ...

Plasmid borne carbapenem resistance has become a serious global threat in hospital settings As hospitals face a dwindling number of treatment options there is a great urgency to track the movement of carbapenem resistant plasmids and the associated resistant genes While whole genome sequencing has great diagnostic potential plasmids pose a unique set of challenges as they lack a clear well de ...

The development of an effective vaccine is the most plausible approach to eliminate the HIV AIDS pandemic The detection of broadly neutralizing antibody bNABs responses is critical for vaccine development In this grant application we propose to develop a novel sensitive method for bNAB detection and quantification An HIV Rev dependent A R derived reporter cell line Rev A R NanoLuc Hal ...

Influenza is a continuing worldwide public health problem associated with significant morbidity and mortality Seasonal influenza epidemics affect about of the worldandapos s population and annual estimates of mortality range from deaths Due to constant antigenic drift the approved seasonal influenza vaccine is variably effective from year to year and a universal vaccine ...

Summary Abstract Hypertension is a leading cause of excess cardiovascular morbidity and mortality and remains a signi cant national problem with approximately one third of all adults having high blood pressure BP BP monitoring has high diagnostic and prognostic value as an important marker of cardiovascular disease Static BP snapshots which are typically obtained via sphygmomanometry during ...