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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enhanced Membranes for Sweetening of Manure based BioGas

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 88

    Every year over 1 billion tons of fresh animal manure is produced in US and it raises pollution concerns. "Anaerobic digestion" is an environmental friendly and energy efficient way to dispose animal manure. Animal manure is converted to biogas and digestate through this process. The animal manure digestate has a much less pollution potential than untreated animal manure and can be used as a chemi ...

    SBIR Phase I 2016 Department of Agriculture
  2. Novel SCD1 inhibitors for treatment of cancer

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    DESCRIPTION provided by applicant Metastatic clear cell renal cell carcinoma mccRCC is an incurable cancer with a year survival of less than for which novel therapeutic agents need to be developed urgently It is notoriously resistant to chemotherapy and radiation Although molecularly targeted therapies have led to an improvement in survival the benefit is rather limited due to event ...

    STTR Phase I 2016 Department of Health and Human Services
  3. A microchip to analyze trafficking leukocytes in Alzheimer’s disease patients

    SBC: IsoPlexis            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most common neurodegenerative diseases that lead to detrimental outcomes such as progressive memory deficit and cognitive impairment Although it is expected that the prevalence of AD will double over the next years currently no widely accepted molecular biomarkers for early detection or non invasive monitoring ...

    SBIR Phase I 2016 Department of Health and Human Services
  4. Leveraging advanced clinical phenotyping to enhance problem lists and support value-based healthcare

    SBC: VMT, INC.            Topic: NLM

    Project Summary As United States healthcare seeks to address inconsistent quality and overwhelming cost data and technology have become central to all suggested approaches With newly available electronic health data and massive growth in processing power the hardest challenges in using clinical data are becoming clear Big data holds the potential to enable personalized patient care population ...

    SBIR Phase I 2016 Department of Health and Human Services
  5. Single-cell multi-protein device for informative cellular function evaluation

    SBC: IsoPlexis            Topic: 100

    DESCRIPTION provided by applicant ELISpot including its variant FLUOROSpot remains the mainstay to measure true secretion of single cells and to assess cellular function e g immunity in the pre clinical and clinical settings However because it measures only one or two proteins per single cell and provides minimal biological information it has limited utility for measuring cell biology an ...

    SBIR Phase I 2016 Department of Health and Human Services
  6. A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis

    SBC: GLYCOMIRA, LLC            Topic: NIAID

    PROJECT SUMMARY This proposal aims to develop a therapeutic capable of preventing and treating the severe sinus inflammation associated with chronic rhinosinusitis CRS CRS is a debilitating inflammatory disease of the sinuses that impacts over million Americans and substantially diminishes the quality of life and productivity of affected patients From to the total US health care ...

    SBIR Phase I 2016 Department of Health and Human Services
  7. Precision Quality Check of Immunotherapeutics via Single Cell Cytokine Mapping

    SBC: IsoPlexis            Topic: 102

    Despite the demonstrated benefit of CD targeted CAR T immunotherapeutics two challenges remain to bringing the therapeutics to market The first key challenge is to reproducibly manufacture the therapy so that the cellsandapos cytokine mediated function acts in a predictably consistent fashion post manufacturing The second key challenge is to manage the cellandapos s adverse effect immuno to ...

    SBIR Phase I 2016 Department of Health and Human Services
  8. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Enhancing Quality of Life for Disabled Patients via High Humidified Flow

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NA

    The goal of this project is to develop a lightweight and compact system that provides 51 percent oxygen enriched air at four to six liters per minute equivalent pure oxygen to individuals with chronic obstructive pulmonary disease (COPD). Existing systems may not deliver a high-enough supply of oxygen to support these individuals who may be capable of activity and for whom increased activity would ...

    SBIR Phase I 2016 Department of Health and Human Services
  10. Isocyanate-Free Polyurethane Resins for One-Component, Ambient-Cure Coatings

    SBC: RENUVIX LLC            Topic: 15NCER04

    Due to their exceptional properties, polyurethane coatings are used extensively in our society.Unfortunately, the socyanate-functional components used in the curing of polyurethanes are generally toxic. Thus, there is a need for polyurethane resins that can be cured without the use of isocyanate-functional components. In addition to enabling the production of polyurethane coatings that are free ...

    SBIR Phase I 2016 Environmental Protection Agency

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