Award Data

We propose to develop an innovative concept of the high speed dynamic IRSP that combines components and devices from proven suppliers with novel system-level research topics from CDS and University of Delaware. Having previously built and delivered working LED IRSPs to users gives CDS a unique advantage. In line with system theme of the solicitation, our phase 1 research topics are focused on syst ...

DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

DESCRIPTION (provided by applicant): The number of patients treated for antibiotics-resistant infections has increased drastically in recent years. What started as a problem primarily associated with hospital-acquired Enterococcus infections, has not only moved into the general community, but also grown to include a number of widespread and serious pathogens. Drug-resistant Streptococci, Staphyloc ...

Abstract The primary liver cancer including intrahepatic bile duct cancer pose significant global burden of illness with increasing incidence and mortality in US and around the world. Surgery remains the most effective form of treatment. However, surgical complication rates for medium to high complexity hepatectomies persist in 30-40% range even in highly skilled hands and at high volume centers. ...

DESCRIPTION (provided by applicant): The recently identified ykvM gene family encodes an enzyme belonging to a unique family of nitrile oxido-reductases that catalyze the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine, a transformation never before observed in biology. Nitrile containing compounds are ubiquitous in the pharmaceutical, agricultural, and chemical industries, wh ...

PROJECT SUMMARY Understanding the brain is a profound and fascinating challenge, captivating the scientific community and the public alike. The lack of effective treatment for most brain disorders makes the training of the next generation of neuroscientists, engineers, and physicians a key concern. However, much of neuroscience is perceived to be too difficult to be taught in school. Having alread ...

The objectives of this proposal are to develop an animal surrogate finite element (FE) model and environment that can be used as a tool to investigate injury mechanisms and mitigation of traumatic brain injury (TBI) due to blast overpressure. A rat head model with a high degree of anatomical detail will be refined for used within an FE blast environment. To avoid the use of unnecessarily costly ...

DESCRIPTION (provided by applicant): Biosensors provide rapid data containing information on molecular interactions that are not easily available using equilibrium assays or histochemical methods. This study will be the first of a series with long-term ob

Recent and emerging technologies, such as a 3-D LADAR tracker with precise target detection, tracking, and aimpoint imaging could make significant gains for ABL’s capabilities. Solid state avalanche photodiodes (APDs) are a rugged, fully-monolithic detector technology well suited for LADAR focal plane arrays (FPAs). In the past, Geiger mode APD operation has been preferred for tasks requiring se ...

To provide the Airborne Laser (ABL) precision ranging and 3-D track refinement capability for the next generation active ranging system (NGARS), Voxtel will develop an avalanche photodiode (APD) receiver. Unlike the original ARS, which uses a 10.6 µm CO2 laser, Voxtel’s InGaAs-based ARS receiver is designed for high-speed photon counting between 1.0 – 1.6 µm. Operation in the short-wave infr ...