Award Data

Modern drug discovery is facilitated by investigating, understanding and exploiting the interaction of defined molecules within complex biological systems. The interface of computational and biomolecular sciences enables the exploitation and development of new paradigms for production of vital therapeutic agents. Success in the contemporary biopharmaceutical arena will require improvements in comp ...

Our initiative to design agents to combat Plasmodium falciparum, the most debilitating of several malaria strains, combines powerful bioinformatic techniques to develop protein target structures with a multifaceted strategy for rational drug design. Using the available x-ray crystal structure of CDK2 as a structural template, we will generate and validate three-dimensional structural models of th ...

New computer-based modeling and data mining tools are continuously being developed to help assess and exploit targets uncovered in genomic research. Traditional computer-aided drug design software has several serious shortcomings. Cross-vendor incompatibilities induce users to use single software exclusively. The user's ability of `Mix & Match' software, unattainable with any current offering, h ...

Sequencing the human genome has uncovered numerous putative novel targets for which 3D structures are not available and which have no known inhibitors. We proposed a system to use computational methodologies to generate 3D molecular models of target proteins, and to use these models to design novel chemical inhibitors. Currently, the system is capable of accurately folding a target's amino acid se ...

We propose a new active broadband electromagnetic (EM) sensor to detect and classify naval mines buried in the littoral. The sensor will work like an underwater metal detector, but it will operate at multiple programmable frequencies suitable to a given littoral environment. Once it detects a potential target, the sensor will interrogate the target and measure its spectral responses (inphase and q ...

We address a key challenge in many military and commercial systems: the tracking of materials and/or documents, and the certification of their origin(watermarking). We use libraries of taggants composed of synthetic DNA, where: (i) the number of distinct taggants are scalable to the millions and more, (ii) the taggants are not easily detectable without certain secret information, but (iii) with t ...

The US Navy seeks science and technology feasibility research emphasizing innovative imagery and data fusion approaches for intelligence, surveillance, reconnaissance, and exploitation (i.e., ISR). Interest includes using data from multiple sensors/systems for comprehensive and timely ISR, supporting operational users in joint force battlespace environments. We propose to research and develop l ...

The objectives of this proposed Phase II project are to develop the appropriate optics for an 8 wavelength CWDM system and demonstrate both the multiplexed data link and the integration of the link with an aircraft actuator. Fly-by-light (FBL) systems have been the subject of research for many years; however, there are still several hurdles to overcome before FBL systems can provide the next adva ...

Kyma Technologies, Inc. will demonstrate high-performance gallium nitride (GaN) microelectronic devices for X-band radar applications using single crystal semi-insulating GaN substrates. FETs for power amplifiers will benefit from lower defects resulting from growth on a native GaN substrate. The thermal conductivity of the GaN substrates will be characterized and device structures will be modeled ...

Development of three Bipropellant Tank designs with mechanically linked pistons for Advanced Small Missile Systems. The study will consider the technical and fabrication issues associated with the design, and rate the comparative merits leading to the selection of Phase II continuation.