Award Data

This Small Business Innovation Research Phase I project is aimed at development of a novel, low-cost process for manufacturing environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) in aviation gas turbines. A key limitation for CMC adoption is the unavailability of inexpensive, truly gas impervious EBCs to provide required CMC engine service life. While novel EBC compositions ...

Abstract Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher efficiency sample preparation processes Sample preparation before high resolution analytical methods such as HPLC or LC MS can require effort and cost nearly equivalent to the actual sample analysis and data reduction Often sample preparation for proteomic glycoproteom ...

Autoimmune disease AD affects up to million Americans which costs approximately $ billion on health care annually and accounts for one of the leading causes of death in women T cells and cytokine function play an important role in autoimmune diseases such as Type Diabetes Multiple Sclerosis Rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE The most successful auto i ...

Adoptive transfer of autologous T cells engineered to express chimeric antigen receptorsCARshas emerged as a promising immunotherapy for patients with hematologic malignanciessuch as CDCARs in leukemias and lymphomasHoweverchallenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell productsince infused cellsasliving drugscan be activated and release a varie ...

Ethylene demand is expected to increase by 50% domestically and worldwide over the next 5 years. Much of this and future growth is likely to be met from shale gas based ethane. Dr. Anne Gaffney of the US-DOE has invented a mixed metal oxide catalyst, M1, for the oxidative dehydrogenation of ethane (C2- ODH) to ethylene at high conversions and very high selectivities. A major hurdle for commercial ...

Synchrotron-based science has had a great scientific impact and will continue to have great impact going forward. In spite of the large investment in the 3rd generation light sources, most beam lines do not preserve the source’s phase profile or brightness all the way to the sample. For these high brightness light sources, errors are almost completely due to distortion ...

Tracking both the extent of the induced fracture and the distribution of the proppant within the fracture are critical in understanding and optimizing the hydraulic fracture processes. Several groups are studying the use of electromagnetic methods and electrically conductive proppants to image the post-fracture proppant distribution. Interpreting these large-scale electromagnetic surveys will like ...

Applied Diamond will make large area particle detectors of CVD diamond for use in nuclear physics experiments at DOE and other laboratories. These detectors will reduce the operating expense and increase the capabilities of these facilities accelerating advances in nuclear science.

This program develops a novel membrane module which produces low cost oxygen enriched air. This program will 1) reduce energy requirements for small or medium size furnaces by up to 60% and 2) provide high CO2 concentration exhaust streams for enhanced concentrating of CO2 for CO2 sequestering.

Gray cast iron piping is the most common pipe material in North America. Based on the high carbon content, graphitic needles or flakes are a common feature in these alloys. As a result, these areas of super-saturated carbon will consistently establish galvanic attack of the adjacent iron matrix, especially when in the presence of most ionic liquids. The localized galvanic potentials create microsc ...