Award Data

DESCRIPTION (provided by applicant): This program will develop a new stable, high flux membrane for osmotic distillation (OD) as a concentration technique for the unprocessed pharmaceutical products from aqueous fermentation broths. Osmotic distillation (O D) is a potentially useful procedure to partially or totally remove water from thermally labile pharmaceutical compounds without exposing the p ...

DESCRIPTION (provided by applicant): We propose applying innovative measurement technology to develop and disseminate a comprehensive function and disability assessment instrument for use in gerontological research and practice. This technology offers an e ffective method to resolve the classic conflict between practicality and psychometric adequacy faced by traditional standardized outcome measur ...

DESCRIPTION (provided by applicant): Our objective is to achieve a major advance in the technology used to assess disability in children and youth. Measurement and practical requirements for identifying disability and evaluating individual progress across pediatric age groups and care settings present a serious dilemma to current fixed-item survey instruments. In Phase I proposals, we have develo ...

The long-term objective is to develop a highly secure, patient-friendly system for patients living with advanced cancer and their family caregivers to enable at-home symptom management and surveillance

DESCRIPTION (provided by applicant): Clostridium difficile-associated disease (CDAD) is a hospital-acquired problem following routine antibiotic treatment. Its impact may exceed that of any other nosocomial infection. Spores of the toxin-producing pathogen are highly resistant to antibiotics and therefore overgrow the gut when broad-spectrum oral antibiotics kill off the competing bacteria. The C ...

DESCRIPTION (provided by applicant): Approximately 35,000 Americans are diagnosed with renal cell carcinoma each year. The disease kills about 12,000 Americans each year and has the highest mortality rate of all urologic cancers (about twice the mortality rate of prostate and bladder cancer). In the past, treatment of renal cell carcinoma required surgical removal of the entire affected kidney le ...

DESCRIPTION (provided by applicant): This goal of this SBIR project is to quantify and validate the feasibility and potential for a non- obtrusive, wearable, in-shoe gait-monitoring device for children with Cerebral Palsy (CP). It is hypothesized that continuous monitoring and analysis of simple gait parameters in children with CP outside the clinical laboratory and during normal daily activities ...

DESCRIPTION (provided by applicant): Despite the high mortality and morbidity of lung diseases, they are frequently difficult to diagnose and phenotype, especially in the early, potentially better treatable stages. For childhood lung disease, the case bec omes even more compelling because the primary imaging modalities for the lung expose the child to ionizing radiation, and children are more rad ...

DESCRIPTION (provided by applicant): Hyperpolarized xenon-129 (HXe) MRI has been demonstrated to have exquisite sensitivity for functional diagnostic imaging of lungs, likely the most technically promising and commercially viable technique. Full characteri zation of pulmonary health may benefit from as many as eight different multi-liter protocols, which should ideally be completed in well under a ...

DESCRIPTION (provided by applicant): Hyperpolarized gas MRI offers unprecedented pulmonary functional diagnostic capability. Individual sufferers of COPD could benefit from improved diagnosis and treatment management, while pharmaceutical companies could h ave more precise measures of the efficacies of their disease- modifying interventions. The US healthcare budget could benefit if the 35B spent ...