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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enhancing Biosynthesis of Biofuels from Cellulosic Biomass (Topic 8.8)

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 88

    This program will provide low cost routes for biosynthesis of these and many other organics. Using biomass for production of fuels and chemical provides for a domestic, renewable and green route to address our fuel and chemical needs. This program provides a simple and inexpensive route for generating these domestic and renewable products

    SBIR Phase I 2010 Department of Agriculture
  2. Transformational Approach to Managing Major Depressive Disorder Among College Students from Rural Communities

    SBC: ICONIC HEALTH, LLC            Topic: 86

    Rural college students have a significant need for improved quality and efficiency mental health services for Major Depressive Disorder. Iconic Health proposes to address this need by building upon the HomePsych communication platform, integrating a process whereby mobile symptom reporting is visually formatted for enriched understanding by mental health professionals. The HomePsych communication ...

    SBIR Phase I 2010 Department of Agriculture
  3. EpiMapVis: A dynamic web-based climate change and remote sensing visualization an

    SBC: APPLIED GEOSOLUTIONS LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Many infectious diseases and chronic illnesses have underlying spatiotemporal relationships with the environment that are challenging to integrate into public health strategies. Compounding this challenge is the growing threat from climate change and lack of actionable information. Access to pertinent geospatial data, disparate data sources, and lack of data us ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Combination Therapy of Aspirin and Apyrase for Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. We will validate hypothesis that in thromboembolic model of stroke in rats, combination tre ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Surface Enhanced Biocompatible Blood Oxygenators

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative effects. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respi ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Facile Detection of Soil-Transmitted Helminth Infections

    SBC: Divergence, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infections from whipworm (Trichuris), roundworm (Ascaris), and hookworms (Necator and Ancylostoma) create a substantial burden to worldwide public h ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Direct RT-PCR detection of RNA pathogens and mRNA expression in crude samples

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop a highly simplified and improved method of detecting RNA for use in clinical tests and for scientific research by enabling the RT-PCR amplification of nucleic acids directly in whole blood, serum, plasma, and cell lysates. We propose a dual approach. We will work with two of our blood inhibition Taq mutants combined with a viral reverse tr ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. TCR-less Targeted T Cells Against Cancer

    SBC: CELDARA MEDICAL, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): This year cancer will become the leading cause of death worldwide. The global burden of cancer doubled between 1975 and 2000. By 2020, it is projected to double again, and to triple by 2030. Ideally, any cancer therapy should be effective (at killing cancerous cells), targeted (i.e. selective, to avoid killing healthy cells), permanent (to avoid relapse and met ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. ChNKG2D-Targeted Cellular Cancer Therapy: Preclinical Toxicology

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Cancer is projected to become the leading cause of death worldwide by 2010. The global burden of cancer doubled between 1975 and 2000. By 2020, it is projected to double again, and to triple by 2030. Multiple myeloma (MM) is a particularly deadly type of cancer. In 2008, 19,920 Americans were diagnosed with MM, and 10,690 died. Five-year survival rates are on ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Angiogenesis antagonist plus CD40-TLR agonist adjuvant combination vaccine

    SBC: IMMURX LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): The early infiltration by leukocytes into the tumor microenvironment leads to neovascularization, enhanced tumor growth, metastasis and lethality of the host. Notably, leukocytes enable tumor establishment, as suggested early on by Virchow in 1826 and proven more recently by others (e.g. Manning et al, 2007 Clin Ca Res 13:3951; review Wasiuk/Noelle et al. 2009 ...

    SBIR Phase I 2010 Department of Health and Human Services

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