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A sustainable supply of renewable biofuel will contribute to the Nation's energy security. Algal biomass is seen as having potential to be a significant source of renewable bioenergy. Microalgae-derived biofuel provides a high oil productivity with a smaller land footprint than terrestrial biofuel crops. It captures carbon dioxide and can grow on marginal lands or with salty aquifer water or w ...

Every year over 1 billion tons of fresh animal manure is produced in US and it raises pollution concerns. "Anaerobic digestion" is an environmental friendly and energy efficient way to dispose animal manure. Animal manure is converted to biogas and digestate through this process. The animal manure digestate has a much less pollution potential than untreated animal manure and can be used as a chemi ...

DESCRIPTION provided by applicant Metastatic clear cell renal cell carcinoma mccRCC is an incurable cancer with a year survival of less than for which novel therapeutic agents need to be developed urgently It is notoriously resistant to chemotherapy and radiation Although molecularly targeted therapies have led to an improvement in survival the benefit is rather limited due to event ...

DESCRIPTION provided by applicant This proposal investigates the use of a novel passive personal monitoring system to stem the tide in the epidemic of deaths due to unintentional opioid drug overdoses In the U S in opioid drug overdoses including prescription pain relievers and heroin caused deaths a number that has increased dramatically over the past two decades A person w ...

DESCRIPTION provided by applicant The adoption of Electronic Health Record EHR systems is growing at a fast pace in the U S and this growth results in very large quantities of patient clinical data becoming available in electronic format with tremendous potentials but also equally growing concern for patient confidentiality breaches Secondary use of clinical data is essential to fulfill ...

DESCRIPTION provided by applicant Alzheimerandapos s disease AD is one of the most common neurodegenerative diseases that lead to detrimental outcomes such as progressive memory deficit and cognitive impairment Although it is expected that the prevalence of AD will double over the next years currently no widely accepted molecular biomarkers for early detection or non invasive monitoring ...

Project Summary The long term objective of this project is to develop a new class of broad spectrum antibiotics focused on Gram negative bacteria Inspired by a natural product this class targets an unexploited binding site of the bacterial ribosome With ever increasing reports of resistance to frontline therapies addressing Gram negatives there is a critical need for new therapies yet very ...

DESCRIPTION provided by applicant This proposal addresses topics of interest to the NIEHS Advanced Training Technologies ATT Program to andquot develop ATT products that will support high quality health and safety training for hazardous materials workers emergency responders and skilled support personnel andquot We propose to develop a Web based Virtual HAZMAT Response Academy VHRA with ...

DESCRIPTION provided by applicant Concern over toxins and public health threats resulting from Cyanobacterial Harmful Algal Blooms CHABs have gained attention as reoccurring and seasonal blooms persist in many waters It has also been suggested that climate change is increasing the frequency intensity and duration of CHABs Broadly cyanotoxins can be described as having negative health im ...

DESCRIPTION provided by applicant This is a SBIR Phase I application to develop new iron chelating drugs for prevention and treatment of iron overload induced bone loss in patients with thalassemia major TM a rare disease in the US Virtually all TM patients are affected by osteopenia and osteoporosis and these skeletal complications herald and contribute to a general clinical deterioratio ...