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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. To develop a customizable sample sparing

    SBC: Grace Bio-Labs, Inc.            Topic: NIAID

    Proposes to commercially develop a customizable sample sparingeasy to usecost effectiveand highly multiplexed protein microarray platform that will simultaneously measure multipleup toimmunoglobulin isotypes subtypes in the same sample across an entire landscape of multiple antigensThe platform is designed to define different effector functions for antibodies reactive with specifically mapped epit ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR Phase 1 Diagnostics to enable malaria and neglected tropical diseases

    SBC: Hemex Health, Inc.            Topic: NIAID

    While significant progress has been made in reducing malaria prevalence and deathsmalaria elimination remains a difficult goalSelection pressures have driven malaria transmitting mosquitos to new behaviorsrendering vector control methods less effectiveMass drug administration without diagnosis can increase the risk of developing drug resistanceAdditionallyPfalciparum and Pvivax species of malaria ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Optimized Dry Powder Formulation and Delivery for Inhaled Clofazimine

    SBC: CREARE LLC            Topic: NIAID

    Treatment regimens for multi drug resistant tuberculosisMDR TBinvolve a spectrum of second tier drugs delivered over a long periodoften over a yearA drug that has shown promise in short regimenssuch as the Bangladesh regimenis oral ClofazimineCFZbut tolerance to oral CFZ is limitedInhaled delivery could potentially limit adverse effects and maximize delivery to the infected pulmonary tissueFormula ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Discovery of novel helminth immunomodulatory proteins for autoimmune diseases

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    This contract aims to identify novel parasite derived protein candidates as biologics to treat Crohn s and other diseases with high healthcare costs and no truly long term effective treatment optionsWe will screen stage specific proteins from Onchocerca volvulus that conceivably enable this parasitic helminth to chronically infect the human host by continuously modulating the innate and adaptive i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Practical Mass Spectrometry Upgrade for Identifying Fragile Protein Modifications by ECD

    SBC: E-Msion, Inc.            Topic: 400

    The speed resolution and high mass accuracy of modern mass spectrometers have revolutionized proteomics particularly for determining fragile post translational modifications that control most cellular processes Accurate identification and quantitation of phosphorylation sites remain a major challenge in proteomics The key weakness with mass spectrometry for phospho proteomics lies in the metho ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Assembled Porous Silica Membranes for Biomolecule SPE

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    Abstract Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher efficiency sample preparation processes Sample preparation before high resolution analytical methods such as HPLC or LC MS can require effort and cost nearly equivalent to the actual sample analysis and data reduction Often sample preparation for proteomic glycoproteom ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Training the brain with a robotic device for balance recovery in near frail older adults

    SBC: AMES TECHNOLOGY, INC.            Topic: NICHD

    DESCRIPTION provided by applicant The long term goal of this project is to reduce falls in older adults by improving their ability to recover equilibrium during a slip or trip The proposed strategy is to use AMES an FDA cleared non invasive intervention that has been shown to enhance motor performance in able bodied adults and to reduce sensorimotor impairment in both the upper and lower lim ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Dynamic Mining and Contextualization of the Scientific Literature This project creates interactive science articles and collects data metrics accelerating scientific discovery and reproducibility

    SBC: InSilico, Inc            Topic: 172

    The proposed Dynamic Mining and Contextualization of the Scientific Literature DMCSL provides an open lane of communication between authors science journals readers and databases The outcome of this communication portal will be a database containing mineable metadata for researchers reagent supply and biotech companies Data will be available to companies through individualized subscription ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Expanding the Click City Tobacco Prevention Program to Include E cigarettes and Other Novel Tobacco Products

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: NIDA

    The overarching goal of the proposed research is to demonstrate the feasibility of modifying an existing effective computer based tobacco prevention program Click City Tobacco funded by NIH R CA to prevent the initiation of e cigarette use e g e cigarettes and other vaping devices among youth Click City Tobacco is a school based program for th graders with a booster in th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Fixed site and wearable monitors for assessment of personal exposure to airborne chemicals

    SBC: XPLOSAFE, LLC            Topic: 113

    Project Summary Abstract People in all facets of life are exposed to volatile toxins that may cause them to unexplainably sicken The NIEHS Exposure Biology and Exposome Program has the ambitious and worthy goal to track a person s exposures from conception to death and correlate these with biological responses and health outcomes Achieving this goal will require numerous inexpensive sensors that ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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