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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Seat/Bolster/Other

    SBC: ACTIVE SHOCK, INC.            Topic: N/A

    A shock mitigating suspended seat, which places the Special Forces Operator in an optimal ergonomic position, will be developed for use in the NSW 11M RIB. It will feature a semi-actively controlled shock absorber to optimize the suspension for a broadrange of operator weights and sea states. In the Phase I effort, a conceptual design and architecture for both control hardware and software was d ...

    SBIR Phase II 2003 Department of DefenseSpecial Operations Command
  7. Safety-Sensing Independence-Enhancing Wheelchair

    SBC: MOBILEROBOTS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Serious wheelchair accidents have risen to almost 37,000 per year. Users of power chairs are three times as likely to have accidents as users of manual chairs! Many people can neither walk nor successfully navigate a wheelchair, e.g., many with MS, quadraplegia, spinal stenosis, visual and other impairments. The Safety Sensing Independence-Enhancing Wheelch ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  8. Ethanol Production via Consolidated Bioprocessing

    SBC: Advanced Bioconversion Technologies            Topic: N/A

    72808S03-I The conversion of cellulosic biomass to commodity products via biological processing could benefit society by improving energy security, reducing greenhouse gas emissions, and promoting rural economies. However, commercial application is impeded by the current absence of low-cost technology to overcome the recalcitrance of cellulosic biomass. This project will develop a strain of Clo ...

    SBIR Phase I 2003 Department of Energy
  9. Development of Ultrasonic Appratus for Dental Diagnosis

    SBC: AAC International            Topic: N/A

    DESCRIPTION: An ultrasonic diagnostic apparatus has been proposed for Dental applications in determining tooth pathologies such as demineralization/caries, hidden fractures, and formation of abscesses. The equipment adopts a piezoelectric and laser optic hybrid transduction system for interrogation of teeth. Ultrasonic responses of the tooth structure will be analyzed by a pattern recognition expe ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Ultrasonic Appratus for Dental Diagnosis

    SBC: AAC International            Topic: N/A

    DESCRIPTION: An ultrasonic diagnostic apparatus has been proposed for Dental applications in determining tooth pathologies such as demineralization/caries, hidden fractures, and formation of abscesses. The equipment adopts a piezoelectric and laser optic hybrid transduction system for interrogation of teeth. Ultrasonic responses of the tooth structure will be analyzed by a pattern recognition expe ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
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